Results 71 to 80 of about 3,135,157 (294)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Monolithically Integrated Light Feedback Control Circuit for Blue/UV LED Smart Package

IEEE Photonics Journal, 2017
Given the performance decay of high-power light-emitting diode (LED) chips over time and package condition changes, having a reliable output light for sensitive applications is a point of concern.
Zahra Kolahdouz Esfahani, Massoud Tohidian, Henk van Zeijl, Mohammadreza Kolahdouz, Guoqi Zhang   +4 more
doaj   +1 more source

Algorithms for output feedback, multiple-model, and decentralized control problems [PDF]

, 1984
The optimal stochastic output feedback, multiple-model, and decentralized control problems with dynamic compensation are formulated and discussed. Algorithms for each problem are presented, and their relationship to a basic output feedback algorithm is ...
Broussard, J. R., Halyo, N.
core   +1 more source

Limits of feedback control in bacterial chemotaxis

, 2014
Inputs to signaling pathways can have complex statistics that depend on the environment and on the behavioral response to previous stimuli. Such behavioral feedback is particularly important in navigation.
Dufour, Yann S., Emonet, Thierry, Fu, Xiongfei, Hernandez-Nunez, Luis   +3 more
core   +3 more sources

Controlling Cell Migratory Patterns Under an Electric Field Regulated by a Neural Network-Based Feedback Controller

Bioengineering
Electric fields (EFs) are widely employed to promote tissue regeneration and accelerate wound healing. Despite extensive study, the cellular responses elicited by EFs are complex and not well understood.
Giovanny Marquez, Mohammad Jafari, Manasa Kesapragada, Kan Zhu, Prabhat Baniya, Yao-Hui Sun, Hao-Chieh Hsieh, Cristian O. Hernandez, Mircea Teodorescu, Marco Rolandi, Min Zhao, Marcella Gomez   +11 more
doaj   +1 more source

Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy

Molecular Systems Biology, 2007
Robust biological signaling networks evolved, through gene duplications, from simple, relatively fragile cascades. Architectural features such as layered configuration, branching and modularity, as well as functional characteristics (e.g., feedback ...
Ido Amit, Ron Wides, Yosef Yarden
doaj   +1 more source

A Preliminary Prototype High-Speed Feedback Control of an Artificial Cochlear Sensory Epithelium Mimicking Function of Outer Hair Cells

Micromachines, 2020
A novel feedback control technique for the local oscillation amplitude in an artificial cochlear sensory epithelium that mimics the functions of the outer hair cells in the cochlea is successfully developed and can be implemented with a control time on ...
Hiroki Yamazaki, Dan Yamanaka, Satoyuki Kawano   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Walking with wider steps changes foot placement control, increases kinematic variability and does not improve linear stability [PDF]

Royal Society Open Science, 2017
Walking humans respond to pulls or pushes on their upper body by changing where they place their foot on the next step. Usually, they place their foot further along the direction of the upper body perturbation.
Jennifer A. Perry, Manoj Srinivasan
doaj   +1 more source