Results 221 to 230 of about 691,015 (282)

Newly identified human aminoacyl‐tRNA synthetase complex interacting multifunctional protein 2 (AIMP2) loss‐of‐function mutations cause neurodevelopmental defects linked to cell death in a zebrafish model

The FEBS Journal, EarlyView.
Human AIMP2 mutations lead to severe neurodevelopmental defects and brain atrophy. Using patient‐derived fibroblasts from two individuals, we show decreased AIMP2 protein levels and overall protein synthesis. In a zebrafish loss‐of‐function model, the lack of AIMP2 leads to an increase in cell death and results in smaller brains.
Patrick Mullen, Shenela Lakhani, Joshua Appelbaum, DéJenaé See, Pryce Patterson, Collin M. MacLeod, Alexandra George, Reza Maroofian, Margaret E. Ross, Christopher Francklyn, Alicia M. Ebert   +10 more
wiley   +1 more source

Modifying feeding protocols in critically ill patients based on a predictive model of feeding intolerance: protocol for a multicenter cluster randomized controlled trial (the mNEED study). [PDF]

Front Med (Lausanne)
Wang Y, Li Y, Chen Y, Zhang Y, Feng X, Lv D, Chen Y, Bi X, Yu Y, Peng Y, Li H, Zhang D.   +11 more
europepmc   +1 more source

Dietary counselling and exercise training for lipid management in people living with HIV: A systematic review and meta‐analysis

HIV Medicine, EarlyView.
Abstract Objectives Dyslipidaemia is highly prevalent among people living with human immunodeficiency virus (HIV) and contributes to increased cardiovascular risk. Although lifestyle interventions are recommended, evidence specific to people living with HIV remains limited. Previous reviews have primarily focused on dietary interventions or low‐density
Maki Aomori, Hitomi Maeda
wiley   +1 more source

MyD88‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions

Immunology, EarlyView.
MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Seshu Vardhan Pothabathula, Saurabh Mishra, Pugazhendhi Kannan, Annette Bellar, Amy Attaway, Nicole Welch, Srinivasan Dasarathy   +6 more
wiley   +1 more source

Self‐administered single‐session interventions for mental health in young people: A systematic review and meta‐analysis

Journal of Child Psychology and Psychiatry, EarlyView.
Background Children and young people's mental health is an area of concern worldwide. In the face of barriers such as long waits to access evidence‐based treatment, perceived stigma, and a desire to tackle challenges independently, self‐administered single‐session interventions (SSIs) have arisen as one potential solution.
Jessica Ball, Richard Meiser‐Stedman, Zoe Thompson, Kenny Chiu   +3 more
wiley   +1 more source

Citrobacter and Acinetobacter are respectively involved in feeding intolerance in preterm infants of different gestational ages: a prospective case-control study. [PDF]

Ital J Pediatr
Fu C, Xu J, Wang H, Chen D, Liu Z.
europepmc   +1 more source

Heat shock protein 72 attenuates atherosclerosis in apolipoprotein E‐deficient mice

Journal of Diabetes Investigation, EarlyView.
Heat shock (HS) + mild electrical stimulation (MES)‐induced heat shock protein (HSP)72 expression prevents atherogenesis in HSP72+/+/ApoE−/− mice. HS + MES‐induced HSP72 expression reduces macrophage infiltration, oxidative stress, JNK activity, and MCP‐1 expression, and alters macrophage polarity from M1 to M2.
Rintaro Yoshizumi, Tatsuya Kondo, Takuro Watanabe, Nobukazu Miyakawa, Sayaka Kitano, Mary Ann Suico, Miki Sato, Masaji Sakaguchi, Motoyuki Igata, Takeshi Matsumura, Hirofumi Kai, Eiichi Araki, Naoto Kubota   +12 more
wiley   +1 more source

[Early warning value of functional ultrasound monitoring parameters for feeding intolerance in preterm infants]. [PDF]

Zhongguo Dang Dai Er Ke Za Zhi
Zhao MR, Wang YL, Zhang JT, Yang X, Zhang X.   +4 more
europepmc   +1 more source

Polar cod Boreogadus saida occurrence is driven by temperature at the margin of its distribution

Journal of Fish Biology, EarlyView.
Abstract With a warming Arctic, suitable habitat for polar cod Boreogadus saida (Lepechin 1774) is predicted to decrease. We investigated the changes in distribution of polar cod on the southern limit of its distribution in the Atlantic Ocean (around Iceland) during both autumn and spring after a recent period of warming in the area.
James Kennedy, Christophe Pampoulie
wiley   +1 more source

Early Maintenance and Change of Planned Removable Prosthodontic Treatment Pathways in Patients With Functional Limitations: The Role of Impression Feasibility and Caregiver Support

Journal of Oral Rehabilitation, EarlyView.
In adults with functional limitations undergoing planned removable prosthodontic treatment, early pathway change (conversion to implant‐based rehabilitation or treatment abandonment) occurred in 22.4% of patients, most within 12 weeks. Impression feasibility under routine outpatient conditions and high caregiver support were independently associated ...
Soo‐Yeon Yoo, Seong‐Kyun Kim, Jai‐Young Koak, Ji‐Man Park, Kwang‐Suk Seo   +4 more
wiley   +1 more source