Results 31 to 40 of about 363,775 (271)

ERDRP-0519 inhibits feline coronavirus in vitro. [PDF]

BMC Vet Res, 2022
Abstract Background Coronaviruses (CoVs) are major human and animal pathogens and antiviral drugs are pursued as a complementary strategy, chiefly if vaccines are not available. Feline infectious peritonitis (FIP) is a fatal systemic disease of felids caused by FIP virus (FIPV), a virulent pathotype of feline enteric ...
Camero M, Lanave G, Catella C, Lucente MS, Sposato A, Mari V, Tempesta M, Martella V, Buonavoglia A.   +8 more
europepmc   +6 more sources

Feline coronavirus influences the biogenesis and composition of extracellular vesicles derived from CRFK cells. [PDF]

Front Vet Sci
Introduction Coronavirus (CoV) has become a public health crisis that causes numerous illnesses in humans and certain animals. Studies have identified the small, lipid-bound structures called extracellular vesicles (EVs) as the mechanism through which ...
Wijerathne SVT, Pandit R, Ipinmoroti AO, Crenshaw BJ, Matthews QL.   +4 more
europepmc   +2 more sources

Comparative in vivo analysis of recombinant type II feline coronaviruses with truncated and completed ORF3 region. [PDF]

PLoS ONE, 2014
Our previous in vitro comparative study on a feline coronavirus (FCoV) pair, differing only in the intactness of their ORF3abc regions, showed that the truncated ORF3abc plays an important role in the efficient macrophage/monocyte tropism of type II ...
Ádám Bálint, Attila Farsang, Zoltán Zádori, Sándor Belák   +3 more
doaj   +10 more sources

Molecular detection using hybridization capture and next-generation sequencing reveals cross-species transmission of feline coronavirus type-1 between a domestic cat and a captive wild felid. [PDF]

Microbiol Spectr
Feline coronavirus (FCoV) infection normally causes mild or subclinical signs and is common in domestic cats. However, in some cats, FCoV infection can also lead to the development of feline infectious peritonitis (FIP)—a typically lethal disease.
Olarte-Castillo XA, Goodman LB, Whittaker GR.   +2 more
europepmc   +2 more sources

One-step triplex TaqMan quantitative reverse transcription polymerase chain reaction for the detection of feline coronavirus, feline panleukopenia virus, and feline leukemia virus. [PDF]

Vet World
Background and Aim: Feline coronavirus (FCoV), feline panleukopenia virus (FPV), and feline leukemia virus (FeLV) are prevalent throughout China and significantly threaten cat health.
He M, Feng S, Shi K, Shi Y, Long F, Yin Y, Li Z.   +6 more
europepmc   +2 more sources

Feline gut microbiota composition in association with feline coronavirus infection: A pilot study

Research in Veterinary Science, 2019
Feline coronaviruses (FCoV) colonize the intestinal tract, however, due to not fully understood mutations, they can spread systemically and cause feline infectious peritonitis (FIP). Recent studies on human medicine report that gut microbiota is involved in the development of systemic disorders and could influence the immune response to viral diseases.
Sara Meazzi, Angelica Stranieri, Stefania Lauzi, Federico Bonsembiante, Silvia Ferro, Saverio Paltrinieri, Alessia Giordano   +6 more
openalex   +4 more sources

Mind the feline coronavirus: Comparison with SARS-CoV-2. [PDF]

Gene, 2022
Both feline coronavirus (FCoV) and SARS-CoV-2 are coronaviruses that infect cats and humans, respectively. However, cats have been shown to be susceptible to SARS-CoV-2, and FCoV also had been shown to infect human.
Gao YY, Liang XY, Wang Q, Zhang S, Zhao H, Wang K, Hu GX, Liu WJ, Gao FS.   +8 more
europepmc   +2 more sources

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

Nature Communications, 2020
Coronavirus main protease is essential for viral polyprotein processing and replication. Here Vuong et al. report efficient inhibition of SARS-CoV-2 replication by the dipeptide-based protease inhibitor GC376 and its parent GC373, which were originally ...
Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, Elena Arutyunova, Tess Lamer, Justin Shields, Holly A. Saffran, Ryan T. McKay, Marco J. van Belkum, Michael A. Joyce, Howard S. Young, D. Lorne Tyrrell, John C. Vederas, M. Joanne Lemieux   +13 more
doaj   +2 more sources

Functional Analysis of Human and Feline Coronavirus Cross-Reactive Antibodies Directed Against the SARS-CoV-2 Fusion Peptide

Frontiers in Immunology, 2022
To face the continuous emergence of SARS-CoV-2 variants, broadly protective therapeutic antibodies are highly needed. We here focused on the fusion peptide (FP) region of the viral spike antigen since it is highly conserved among alpha- and ...
Nathalie Vanderheijden, Annelies Stevaert, Jiexiong Xie, Xiaolei Ren, Cyril Barbezange, Sam Noppen, Isabelle Desombere, Bruno Verhasselt, Peter Geldhof, Nick Vereecke, V. Stroobants, Da-Young Oh, Merijn Vanhee, Lieve Naesens, Hans Nauwynck   +14 more
openalex   +2 more sources

Feline Coronavirus Infection: Genomics and Epizootology

Ветеринарная патология, 2023
Introduction. The issue of coronavirus infection prevalence in cats is still acute. Particular danger of infecting the animals lies in possible mutations of the virus, the asymptomatic course of the disease, high prevalence of the virus carriage in cats ...
E. V. Tkacheva, M. Yu. Vakulenko, I. V. Popov, A. M. Ermakov   +3 more
doaj   +2 more sources