Results 41 to 50 of about 6,407 (212)

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

Cytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith, Lauren A. Tauer, Randall H. Friedline, Xiaodi Hu, Duy Tran, Yangyi E. Luo, Nacima Hadjout‐Rabi, Elisabeth R. Barton, Jason K. Kim, Elizabeth J. Luna   +9 more
wiley   +1 more source

Evaluating Vaginal Microbiome Effects on Antiretroviral Exposure in the Female Genital Tract Using Pharmacometric and Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Antiretroviral pre‐exposure prophylaxis (PrEP) is less effective in women than expected, partly because drug exposure within the female genital tract is variable and may be influenced by the vaginal microbiome. We developed an integrated pharmacometrics and machine learning framework to evaluate associations between vaginal microbiome composition and ...
Diqin Yan, Lindsey B. Collins, Christopher Staley, Flavia Kiweewa Matovu, Pamala Jacobson, Melanie Nicol, Shen Cheng   +6 more
wiley   +1 more source

Improving care for women and girls who have undergone female genital mutilation/cutting: qualitative systematic reviews

Health Services and Delivery Research, 2019
Background: In a context of high migration, there are growing numbers of women living in the UK who have experienced female genital mutilation/cutting.
Catrin Evans, Ritah Tweheyo, Julie McGarry, Jeanette Eldridge, Juliet Albert, Valentine Nkoyo, Gina Higginbottom   +6 more
doaj   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

What do we know about assessing healthcare students and professionals’ knowledge, attitude and practice regarding female genital mutilation? A systematic review

Reproductive Health, 2017
Introduction Improving healthcare providers’ capacities of prevention and treatment of female genital mutilation (FGM) is important given the fact that 200 million women and girls globally are living with FGM.
Jasmine Abdulcadir, Lale Say, Christina Pallitto   +2 more
doaj   +1 more source

Female genital mutilation/cutting in Africa [PDF]

Translational Andrology and Urology, 2017
Female genital mutilation/cutting (FGM/C) is a traditional practice in which the external female genitalia is partially or totally incised or excised for a non-therapeutic reason, usually without the consent of the individual. FGM/C is common in Africa with varying prevalence in different countries, though the incidence is reducing because it is ...
Odukogbe, Akin-Tunde A., Afolabi, Bosede B., Bello, Oluwasomidoyin O., Adeyanju, Ayodeji S.   +3 more
openaire   +2 more sources

p16 Overexpression and Human Papillomavirus Positivity in More Than 1000 Penile Cancers

International Journal of Cancer, EarlyView.
ABSTRACT Penile cancer is a severe disease, and a large proportion is related to high‐risk (hr) human papillomavirus (HPV). P16 is used as an immunohistochemical marker of HPV in clinical diagnostics. Population‐based data on the prevalence of p16 in penile cancer is scarce.
Marianne Gardar Stærk, Birgitte Grønkær Toft, Christina Stilling, Johanna Elversang, Sanne Kjær‐Frifeldt, Sonja Höhle Hjulskov, Sanja Stifter‐Vretenar, Marie Aarslev Schou, Mikael Aagaard, Peter Meidahl Petersen, Jakob Kristian Jakobsen, Christian Munk, Susanne Krüger Kjær   +12 more
wiley   +1 more source

Applied surgical anatomical approach to pudendal nerve: Step‐by‐step key neurovascular structures for pelvic nerve surgery

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To define and demonstrate a step‐by‐step surgical anatomical approach to pudendal nerve dissection using female cadavers, focusing on the identification of safe roadmap and key neurovascular structures to optimize pelvic nerve surgery.
Merve Didem Eşkin Tanrıverdi, Ayhan Cömert, Zekiye Gözde Kara, Hasan Onur Topçu, Halil İbrahim Açar   +4 more
wiley   +1 more source

Ritual Genital Cutting of Female Minors [PDF]

Pediatrics, 2010
This Policy Statement was retired May 2010. The traditional custom of ritual cutting and alteration of the genitalia of female infants, children, and adolescents, referred to as female genital mutilation or female genital cutting (FGC), persists primarily in Africa and among certain communities in the Middle East and Asia.
openaire   +5 more sources

Risk factors for not proceeding to reconstructive surgery after female genital mutilation: A cohort study of 220 women in a specialized referral center

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective This study identifies factors associated with not proceeding to clitoral reconstructive surgery among women with female genital mutilation (FGM) enrolled in a specialized surgical pathway. Methods A retrospective cohort study was conducted at a multidisciplinary referral center in Montreuil, France, between January 2021 and December ...
Félicia Joinau‐Zoulovits, Maëlle Silvestre De Sacy, Bruno Renevier, Sarah Abramowicz   +3 more
wiley   +1 more source