Results 281 to 290 of about 178,279 (340)

Aberrant Glycosylation of IgG in Children With Active Lupus Nephritis Alters Podocyte Metabolism and Causes Podocyte Injury

open access: yesArthritis &Rheumatology, EarlyView.
Objective Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes, and decreased nephrin production.
Rhea Bhargava   +9 more
wiley   +1 more source

A tolerogenic plasmid inhibits autoantibody production triggered by immunization with human peptidyl arginine deiminase 4.

open access: yesArthritis &Rheumatology, Accepted Article.
Objectives Rheumatoid arthritis (RA) is usually preceded and likely mediated by autoantibodies to citrullinated proteins (ACPAs) that recognize citrulline residues on multiple proteins. Conversion of arginine into citrulline is performed by enzymes called peptidyl arginine deiminases (PADs).
Philippe P. Pagni   +10 more
wiley   +1 more source

First‐time cefuroxime target tissue concentrations in long‐lasting spine surgery: Continuous evaluation after repeated weight‐dosed administrations

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Antimicrobial prophylaxis is central in preventing postoperative spine infections, yet knowledge on clinical target spine tissue concentrations remain limited. Current dosing regimens often involve fixed doses based on empirical knowledge, surrogate measures, non‐clinical evidence and methodology of variying quality.
Magnus Andreas Hvistendahl   +6 more
wiley   +1 more source

Lipid metabolism reprograming by SREBP1‐PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy

open access: yesCancer Communications, EarlyView.
Abstract Background Pancreatic cancer's aberrant lipid metabolism fuels cell growth, invasion, and metastasis, yet its impact on immune surveillance and immunotherapy is unclear. This study investigated how sterol regulatory element‐binding transcription factor 1 (SREBP1)‐driven lipid metabolism affects the tumor microenvironment (TME) in pancreatic ...
Mengyi Lao   +12 more
wiley   +1 more source

Targeting MAN1B1 potently enhances bladder cancer antitumor immunity via deglycosylation of CD47

open access: yesCancer Communications, EarlyView.
Abstract Background Only a few bladder cancer patients benefit from anti‐programmed cell death protein 1/programmed cell death ligand 1 immunotherapy. The cluster of differentiation 47 (CD47) plays an important role in tumor immune evasion. CD47 is a highly glycosylated protein, however, the mechanisms governing CD47 glycosylation and its potential ...
Jie Zhang   +20 more
wiley   +1 more source

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