Results 51 to 60 of about 245,650 (259)

Molecular genetics and pathophysiology of 17 beta-hydroxysteroid dehydrogenase 3 deficiency. [PDF]

, 1996
Autosomal recessive mutations in the 17 beta-hydroxysteroid dehydrogenase 3 gene impair the formation of testosterone in the fetal testis and give rise to genetic males with female external genitalia.
Andersson, Stefan, Blethen, Sandra L., Bloise, Walter, Cutler Jr., Gordon B., Davis, Daphne L., Geissler, Wayne M., Griffin, James E., Grumbach, Melvin M., Mendonca, Berenice B., New, Maria I., Russell, David D., Schwarz, Hans P., Wilson, Jean D., Witchel, Selma F., Wu, Ling   +14 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Androgenetic alopecia: Clinical features and trichoscopy

Clinical Dermatology Review, 2022
Androgenetic alopecia, known alternatively as male pattern baldness when men are affected, and female pattern hair loss, when it affects women, is a form of alopecia characterized by miniaturization – a process wherein thick, long terminal hair are ...
Shashank Bansod, Aseem Sharma, Madhulika Mhatre   +2 more
doaj   +1 more source

Partial baldness in relation to reproduction in pond bats in the Netherlands [PDF]

, 2009
Meervleermuizen (Myotis dasycneme) vertonen vaak opvallende kale plekken op de rug. Aan de hand van data van meer dan 2200 gevangen meervleermuizen tussen 2003 en 2008 hebben we de mogelijke sociale, eologische en fysiologische oorzaken achter dit ...
Alphen, J., van, Haarsma, A.J.
core   +1 more source

An Examination of body composition measurement methods in children

, 2009
Introduction . Body-composition methods include underwater weighing (UWW), skinfold thickness (SKF), bioelectrical impedance (BIA), and the BOD POD.
Kaplan, Robert
core   +1 more source

OPA1-related auditory neuropathy: site of lesion and outcome of cochlear implantation. [PDF]

, 2015
Hearing impairment is the second most prevalent clinical feature after optic atrophy in Dominant Optic Atrophy associated with mutations in the OPA1 gene.
Arslan, E, Biscaro, A, Cama, Elona, Caporali, L, Carelli, V., La Morgia, C, Liguori, R, Magnavita, V, Monteleone, A, Rossi, R, Santarelli, Rosamaria, Scimemi, Pietro, Valentino, Ml   +12 more
core   +3 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Mapping the disease-specific LupusQoL to the SF-6D [PDF]

, 2015
Purpose To derive a mapping algorithm to predict SF-6D utility scores from the non-preference-based LupusQoL and test the performance of the developed algorithm on a separate independent validation data set.
AM Gray, C Browne, CA Marra, D Feeny, D Rowen, EM Pullenayegum, EM Tan, GR Barton, Ian Bruce, IN Bruce, J Brazier, J Brazier, J Brazier, J Cohen, J Ware Jr, Janice Abbott, JE Brazier, JE Brazier, JE Ware, JR Kirwan, K McElhone, K McElhone, K McELHONE, Kathleen McElhone, L Longworth, Lee-Suan Teh, M Hernández Alava, M Petri, M Sanchez, Mark Harrison, MC Hochberg, MF Drummond, MF Janssen, MJ Harrison, MJ Harrison, MR Gold, N Bansback, PM Fayers, PM Fayers, R Aggarwal, R Ara, R Meacock, Rachel Meacock, S Gabriel, S O’Neill, Sahena Haque, Y Ahmad, Y Yang, Z Touma   +48 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation [PDF]

, 2006
The planar cell polarity (PCP) pathway is conserved throughout evolution, but it mediates distinct developmental processes. In Drosophila, members of the PCP pathway localize in a polarized fashion to specify the cellular polarity within the plane of the
Brinkman, Brendan C., Chen, Ping, Dickinson, Mary E., Fraser, Scott E., Hamblet, Natasha S., Mark, Sharayne, Segil, Neil, Wallingford, John B., Wang, Jianbo, Wynshaw-Boris, Anthony   +9 more
core   +1 more source