Results 111 to 120 of about 3,371,067 (336)
Frontiers in PhysiologyIntroductionDoping remains a persistent concern in sports, compromising fair competition. The Athlete Biological Passport (ABP) has been a standard anti-doping measure, but confounding factors challenge its effectiveness.
Hyunji Ryoo +4 more
doaj +1 more source
Russian women in German universities — pioneers of female higher education? [PDF]
Vestnik of Saint Petersburg University. History, 2016 From the turn of the century till the beginning of World War I students from the Russian Empire formed the largest group of foreign students in Germany. In recent literature, Russian women have even been considered the pioneers of university education for women in Germany where the admission of females as regular students was permitted later that in ...
openaire +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Review: Historical and futuristic developments in bovine semen technology
Animal, 2018 Up to the 18th century, the prevailing view of reproduction, or ‘generation’ as it was referred to, was that organisms develop from miniatures of themselves, termed preformation.
P. Lonergan
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
HistoriesAt the intersection of memory and feminist studies, this article examines the issue of suffrage and feminist monumental commemoration in the United States.
Claire Sorin
doaj +1 more source
Suicide rates in Maltese Islands (1955-2009) analysed in European context using WHO data [PDF]
, 2014 Aim: To calculate the suicide rates (for males and females) in Malta and other European countries with long series of suicide mortality as recorded in the WHO (World Health Organization) database, and compare the Maltese suicide rates with European rates.
Helema, Samuli +2 more
core
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source