Results 41 to 50 of about 128,458 (259)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett   +8 more
wiley   +1 more source

Typical males and unconventional females: songs and singing behaviors of a tropical, duetting oriole in the breeding and non-breeding season

open access: yesFrontiers in Ecology and Evolution, 2016
Recent research emphasizes that female song is evolutionarily important, yet there are still few species for which we have quantified the similarities and differences between male and female song. Comparing song rates and the structure of female and male
Karan J. Odom   +6 more
doaj   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao   +6 more
wiley   +1 more source

The evolution of song in female birds in Europe [PDF]

open access: yesBehavioral Ecology, 2006
Bird song is usually regarded as an attribute of males. However, in some species, females may also produce songs even with comparable complexity to that of males. It has been suggested that female song may evolve due to similar selection pressures acting on males, but no study has yet investigated the evolution of female vocalization in a phylogenetic ...
Garamszegi, László Zsolt   +3 more
openaire   +4 more sources

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen   +7 more
wiley   +1 more source

The Effect of Using Songs on Young Iranian EFL Learners’ Vocabulary Learning: A Case of Gender [PDF]

open access: yesJournal of Modern Research in English Language Studies, 2016
Knowledge can be reflected in vocabulary repertoire; it is thus important to find out effective methods of vocabulary teaching which can assist language learners in the process of vocabulary learning. This study investigated the effectiveness of teaching
Ali Roohani, Somayeh Akbarpour
doaj  

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu   +21 more
wiley   +1 more source

Partners coordinate territorial defense against simulated intruders in a duetting ovenbird

open access: yesEcology and Evolution, 2020
Duets in breeding pairs may reflect a situation of conflict, whereby an individual answers its partner's song as a form of unilateral acoustic mate guarding or, alternatively, it may reflect cooperation, when individuals share in territory defense or ...
Pedro Diniz   +4 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Female finches prefer courtship signals indicating male vigor and neuromuscular ability.

open access: yesPLoS ONE, 2020
Female songbirds use male song to discriminate among individuals and evaluate their quality as potential mates. Previous behavioral experiments in many species, including the species studied here, have shown that females will solicit copulation in ...
Jeffery L Dunning   +3 more
doaj   +1 more source

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