Results 141 to 150 of about 69,678 (337)

Law\u27s Constitution: A Relational Critique [PDF]

open access: yes, 2002
It is a simple fact: we begin from others. Without others we, quite literally, could not live, feel, be born. Every mother, every mother\u27s partner, every father, every child, knows this.
Nourse, Victoria
core   +1 more source

Novel Role of Gut‐Derived Roseburia Intestinalis in Safeguarding Intestinal Barrier Integrity and Microenvironment Homeostasis During Arsenic Exposure

open access: yesAdvanced Science, EarlyView.
Arsenic exposure disrupts intestinal barriers and gut microenvironment. Fecal microbiota transplantation (FMT) alleviates arsenic‐induced damage, with gut‐derived Roseburia intestinalis (R.i) identified as a key protective strain. R.i administration counters arsenic toxicity through immunomodulatory pathways and metabolites.
Lixiao Zhou   +15 more
wiley   +1 more source

Targeting Aurora Kinases as Essential Cell‐Cycle Regulators to Deliver Multi‐Stage Antimalarials Against Plasmodium Falciparum

open access: yesAngewandte Chemie, EarlyView.
In this study, we repurposed human Aurora kinase‐specific inhibitors to identify potential antimalarial agents. Two inhibitors, hesperadin and TAE684, exhibited sub‐micromolar activity across multiple parasite stages, with hesperadin demonstrating significant potency and selectivity by specifically targeting PfArk1.
Henrico Langeveld   +23 more
wiley   +2 more sources

Buprenorphine and postpartum contraception utilization among people with opioid use disorder: a multi-state analysis

open access: yesAddiction Science & Clinical Practice
Background The postpartum period provides an opportunity for birthing people with opioid use disorder (OUD) to consider their future reproductive health goals.
Kevin Y. Xu   +11 more
doaj   +1 more source

Chronic PET‐Microplastic Exposure: Disruption of Gut–Liver Homeostasis and Risk of Hepatic Steatosis

open access: yesAdvanced Science, EarlyView.
Chronic exposure to environmentally relevant PET microplastics disrupts gut–liver homeostasis, leading to hepatic steatosis, early fibrosis, and altered gut microbiota. These effects signal metabolic imbalance and gut–liver axis impairment, emphasizing chronic microplastic ingestion as an emerging environmental health risk linked to non‐communicable ...
Surye Park   +5 more
wiley   +1 more source

Deviancy, Dependency, and Disability: The Forgotten History of Eugenics and Mass Incarceration [PDF]

open access: yes, 2015
Three widely discussed explanations of the punitive carceral state are racism, harsh drug laws, and prosecutorial overreach. These three narratives, however, only partially explain how our correctional system expanded to its current overcrowded state ...
Riseby, Emil, Svensson, Alexander
core   +1 more source

Precision Targeting of Myeloid Cells via Peptide Dendrimer‐Lipid Nanocarriers: A Novel Platform for Potent Cancer Immunotherapies

open access: yesAdvanced Science, EarlyView.
Precision targeting of the spleen and myeloid cells of the tumor microenvironment, with minimal hepatic delivery, is achieved using a modular peptide dendrimer‐lipid nanocarrier. Functional assays, transcriptomics, and rodent models validate this novel myeloid cell targeting nanocarrier as an efficacious immunotherapy, both as a cancer vaccine platform
Lawrence James Billing   +9 more
wiley   +1 more source

The High‐Altitude Adaptation Characteristics of Microbiota‐Host Cross‐Talk in Yak Gastrointestinal Track

open access: yesAdvanced Science, EarlyView.
In this study, a single‐cell atlas of 117,019 yak gastrointestinal cells across 54 subtypes identified HNF4A and SREBF2 as key transcription factors targeting MYO6 gene. Cross‐species and multi‐omics analyses reveals epithelial cells as key regulators that, through interactions with microbes, particularly Bacillus, facilitate flexible energy supply and
Chun Huang   +12 more
wiley   +1 more source

Efficacy, safety, and patient acceptability of the Essure™ procedure

open access: yesPatient Preference and Adherence, 2011
Collette R Lessard, Matthew R HopkinsDepartment of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota, USAAbstract: The Essure™ system for permanent contraception was developed as a less invasive method of female sterilization ...
Hopkins MR, Lessard CR
doaj  

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