Results 251 to 260 of about 69,678 (337)

Protein Catabolites as Blood‐Based Biomarkers of Aging Physiology: Findings From the Dog Aging Project

open access: yesAging Cell, EarlyView.
The Dog Aging Project identifies protein catabolites as biomarkers of age and aging physiology in the Precision Cohort of companion dogs across the United States. ABSTRACT Our understanding of aging has grown through the study of systems biology, including single‐cell analysis, proteomics and metabolomics.
Benjamin R. Harrison   +40 more
wiley   +1 more source

Epigenetic Clock Analysis of Sex Chromosome Aneuploidies

open access: yesAging Cell, EarlyView.
Next‐generation epigenetic clocks indicate lower age acceleration and slower pace of aging in 47,XXY than 46,XX, 46,XY, and 47,XYY. A first‐generation clock (Skin & Blood) indicates higher age acceleration in 47,XXY and 47,XYY than 46,XY, while higher naïve CD8+ T in 47,XXY than both 46,XY and 46,XX suggests reduced immunosenescence.
Joshua Zhang   +7 more
wiley   +1 more source

What transgender individuals in Japan expect from gender-affirming surgery: A multicenter prospective observational study. [PDF]

open access: yesPCN Rep
Yorozuya W   +13 more
europepmc   +1 more source

ER Stress Ire1‐Xbp1s Pathway Maintains Youthful Epidermal Basal Layer Through the Regulation of Cell Proliferation

open access: yesAging Cell, EarlyView.
In young epidermal basal layer, the Ire1‐Xbp1s endoplasmic reticulum (ER) stress‐response pathway maintains cell proliferation by activating the cell cycle regulator Vcp, whereas the age‐dependent decline in glucose metabolism reduces Ire1‐Xbp1s activity, consequently downregulating cell proliferation.
Daniel Semmy   +10 more
wiley   +1 more source

Alcohol and drug use and attainment of pregnancy preferences in the southwestern United States: A longitudinal cohort study

open access: yesAddiction, EarlyView.
Abstract Aims Addressing design and measurement limitations of prior studies, we examined whether individuals who use alcohol or drugs are less likely to attain their pregnancy preferences over one year. Design Longitudinal cohort study. Setting Five southwestern US states.
Sarah Raifman   +2 more
wiley   +1 more source

Temporal associations between ambrosia beetles and ʻōhiʻa (Metrosideros polymorpha) artificially inoculated with Ceratocystis lukuohia

open access: yesAgricultural and Forest Entomology, EarlyView.
Abstract Wood boring ambrosia beetles play a central role in the spread of Ceratocystis wilt of ‘ōhi‘a, a fungal disease caused by Ceratocystis lukuohia that kills the bioculturally important ‘ōhiʻa (Metrosideros polymorpha) tree. Beetles contribute to the spread of the disease by extruding fungus‐infected wood particles (frass). Disease mitigation can
Robert W. Peck   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy