Discontinuing Long‐Term Denosumab in Treating Fragile Bone: Why, for Whom, and How?
Discontinuation of denosumab (Dmab) may be necessary due to adverse events or an unfavorable long‐term risk–benefit profile. However, accumulating evidence demonstrates pronounced rebound phenomena after withdrawal, most notably a marked increase in multiple vertebral fractures, and, in some reports, elevated mortality.
Ko‐Hsiu Lu +5 more
wiley +1 more source
Characteristics and Risk Factors of Atypical Periprosthetic Femoral Fractures Following Total Hip Arthroplasty: A Systematic Review and Meta-Analysis. [PDF]
Ade-Conde AM +4 more
europepmc +1 more source
Abstract Background Bone grafting in equine medicine offers a promising contribution to treating orthopaedic developmental diseases and chondral, osteochondral and segmental bone defects. Among grafts, synthetic bone substitutes—alloplastics—show favourable biological properties addressing numerous limitations presented by autografts, xenografts and ...
Katarzyna Skierbiszewska +6 more
wiley +1 more source
Flexible Intramedullary Nails for Stabilization of Transverse Femoral Fractures in Cats: Ex Vivo Biomechanical Characterization. [PDF]
Abibe RB +7 more
europepmc +1 more source
Femoral Skeletal Growth in Early Infancy Assessed by Radiofrequency Echographic Multi‐Spectrometry
Radiofrequency echographic multi‐spectrometry (REMS) acquisition of raw ultrasound radiofrequency signals from neonatal bone. Signals undergo preprocessing and frequency‐domain analysis to extract spectral features reflecting bone properties. A software‐guided procedure then identifies and selects standardized regions of interest (ROIs).
Serafina Perrone +10 more
wiley +1 more source
Validation of the Neutrophil-Lymphocyte Ratio as a Mortality Risk Stratification Marker in Patients with Proximal Femoral Fractures. [PDF]
Civinini A +5 more
europepmc +1 more source
Abstract Background Sodium alendronate (ALN) is widely used to treat postmenopausal osteoporosis, but both estrogen deficiency and antiresorptive therapy may impair alveolar bone repair after tooth extraction. A clinically relevant but insufficiently explored scenario involves estrogen‐deficient individuals receiving hormone replacement therapy (HRT ...
Pedro H. C. Isaias +9 more
wiley +1 more source
Bisphosphonate-Related Atypical Femoral Fractures: A Comprehensive Review. [PDF]
Mohamed A +4 more
europepmc +1 more source
Abstract The transition from the Last Glacial Maximum to the Late Glacial marked a shift from the cold conditions of Greenland Stadial‐2 (GS‐2) to the warmer phases of Greenland Interstadial‐1 (GI‐1), enabling the reoccupation of Alpine regions by Late Palaeolithic hunter‐gatherers.
Mahym Amanova +2 more
wiley +1 more source
Non-union after bisphosphonate-associated atypical femoral fractures: a review of the current literature. [PDF]
Dowling J, Marsh S, O'Grady J.
europepmc +1 more source

