Results 281 to 290 of about 1,407,592 (395)

Diagnosis of Angelman Syndrome, With 66 Years of Delay, Using Hypothesis‐Free DNA Methylation Profiling

open access: yesClinical Genetics, EarlyView.
Hypothesis‐free DNA methylation profiling in a 66‐year‐old male with unexplained neurodevelopmental disorder enabled the exclusion of ZNF142‐related disease (left panel) and led to a retrospective diagnosis of Angelman syndrome, highlighting the diagnostic potential of single‐patient epigenetic screening (right panel).
Mathis Hildonen   +9 more
wiley   +1 more source

YTHDC1 Modulates the Osteogenic Capacity of hPDLSCs via Wnt/β‐Catenin Signalling Pathway for the Treatment of Bone Defects in Osteoporosis Rats

open access: yesCell Proliferation, EarlyView.
In this study, human periodontal ligament stem cells (hPDLSCs) were successfully isolated and cultivated from the periodontal ligament tissues of healthy premolar teeth. Our in vivo experiments demonstrated that YTHDC1 augmented the osteogenic differentiation capacity of these cells via the Wnt/β‐catenin signalling pathway.
Dan Tan   +8 more
wiley   +1 more source

Accelerating Bone Healing With METTL3 Overexpressed Adipose‐Derived Stem Cells in Osteoporotic Rats

open access: yesCell Proliferation, EarlyView.
METTL3 promotes osteogenic differentiation of osteoporotic adipose‐derived stem cells and accelerates the repair of cranial defect areas in osteoporotic rats by activating the Wnt signalling pathway. ABSTRACT The treatment of postmenopausal osteoporosis (OP) presents a multifaceted challenge.
Hui Tang   +8 more
wiley   +1 more source

Mechanism of EC‐EXOs‐Derived THBS3 Targeting CD47 to Regulate BMSCs Differentiation to Ameliorate Bone Loss

open access: yesCell Proliferation, EarlyView.
EC‐EXOs could regulate the differentiation of BMSCs through the key protein THBS3, which inhibits their differentiation to lipogenic cells and promotes their differentiation to osteoblasts. THBS3 could down‐regulate the expression of its downstream target CD47 and delay the process of bone loss in aged mice and OVX mice, which may provide a novel ...
Jiaojiao Wang   +8 more
wiley   +1 more source

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