Results 91 to 100 of about 1,930,858 (393)

AAV-Anti-miR-214 Prevents Collapse of the Femoral Head in Osteonecrosis by Regulating Osteoblast and Osteoclast Activities

Molecular Therapy: Nucleic Acids, 2019
Osteonecrosis of the femoral head, an intractable but common disease that eventually triggers collapse of the femoral head, is characterized by increased osteoclast activity and markedly decreased osteoblast activity in the necrotic region of the femoral
Cheng Wang, Weijia Sun, Shukuan Ling, Yu Wang, Xin Wang, Haoye Meng, Yuheng Li, Xueling Yuan, Jianwei Li, Ruoxi Liu, Dingsheng Zhao, Qiang Lu, Aiyuan Wang, Quanyi Guo, Shibi Lu, Hua Tian, Yingxian Li, Jiang Peng   +17 more
doaj   +1 more source

A Canine Musculoskeletal Robot for Investigating Biomechanical Functions During Locomotion

Advanced Robotics Research, EarlyView.
In this study, a dog limb musculoskeletal robot was developed using thin McKibben artificial muscles to investigate the effects of the dog's musculoskeletal structure on walking. Walking experiments were conducted in both indoor and outdoor environments, suggesting that the flexible structure of the dog's shoulders contributes to an increase in stroke ...
Hana Ito, Shoma Tanaka, Yunhao Feng, Hiroyuki Nabae, Yasuji Harada, Akira Fukuhara, Koichi Suzumori   +6 more
wiley   +1 more source

Efficacy of Probiotics for Reducing the Incidence of Lameness in Broilers Grown on Wire Flooring [PDF]

, 2013
Growing broilers on wire flooring provides an excellent experimental model for reproducibly triggering significant levels of lameness. In Pilot Study #1 using broilers from Line C grown on wire flooring, adding the Biomin probiotic PoultryStar® to the ...
Stark, John Matthew
core   +2 more sources

The Effects of Interlocking a Universal Hip Cementless Stem on Implant Subsidence and Mechanical Properties of Cadaveric Canine Femora. [PDF]

, 2016
ObjectiveTo determine if an interlocking bolt would limit subsidence of the biological fixation universal hip (BFX(®)) femoral stem under cyclic loading and enhance construct stiffness, yield, and failure properties.Study designEx vivo biomechanical ...
Buks, Yonathan, Garcia-Nolen, Tanya C, Stover, Susan M, Wendelburg, Kirk L   +3 more
core   +1 more source

Bone Microarchitecture and Biomechanics of the Necrotic Femoral Head

Scientific Reports, 2017
The mechanism behind osteonecrosis of the femoral head (ONFH) remains unclear. The aim of this study was to explore the pathogenesis of ONFH from a biomechanical standpoint to provide a theoretical basis for improved treatments.
Jian-xiong Ma, Wei-wei He, Jie Zhao, Ming‐jie Kuang, Hao-hao Bai, Lei Sun, Bin Lu, A. Tian, Y. Wang, Ben‐chao Dong, Yan Wang, Xin-long Ma   +11 more
semanticscholar   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Femoral head translation in borderline and definite dysplastic hips during weight‐bearing: 2D/3D image registration analysis

Journal of Experimental Orthopaedics, 2023
Purpose The aims of this study were to 1) assess femoral head translation during weight‐bearing in symptomatic developmental dysplasia of the hip (DDH) and 2) compare it between borderline DDH and definite DDH. Methods The study included four individuals
Shinichiro Sakai, Tatsuhiko Kutsuna, Kohei Kono, Tomofumi Kinoshita, Naohiko Mashima, Masaki Takao   +5 more
doaj   +1 more source

Assessing the material loss of the modular taper interface in retrieved metal on metal hip replacements [PDF]

, 2015
Measuring the amount of material loss in the case of revised hip replacements is considered to be a prerequisite of understanding and assessing the true in vivo performance of the implant.
Bills, Paul J., Blunt, Liam, Racasan, Radu, Tessier, P   +3 more
core   +1 more source

Epigenetic Targeting of Senescent Cells Prevents the Deleterious Effects of Obstructive Sleep Apnea on Growing Skeleton

Advanced Science, EarlyView.
Chronic intermittent hypoxia induces premature senescence of osteoprogenitor cells in long bone metaphysis via HIF1α‐mediated EZH2‐H3k27me3 downregulation, leading to impaired bone growth. Restoration of H3K27me3 level via UTX inhibition rescues osteogenesis and growth impairment in young mice.
Xiaonan Liu, Peilin Zhang, Zhongyi Su, Yong Feng, Zhenger Zhou, Sa Pang, Yicheng Wang, Jiacheng Hu   +7 more
wiley   +1 more source

Relationship between anterior or posterior femoral head necrosis and collapse based on MRI-defined key necrotic layer sets

Journal of Orthopaedic Surgery and Research
Background Current clinical studies on femoral head necrotic lesions primarily focus on the medial and lateral regions, while detailed MRI-based methods to evaluate the relationship between anterior or posterior necrosis and collapse remain lacking ...
Yawei Dong, Yan Yan, Jun Zhou, Kaiqiang Tang, Xiaohan Wang, Rui Quan, Jiaming Lin, Yan Jia, Zelu Zheng, Baohong Mi, Weiheng Chen   +10 more
doaj   +1 more source