Results 101 to 110 of about 156,306 (356)

Immunometabolic Rewiring of Dendritic Cells to Overcome Glutamine‐Driven Immune Suppression in Colorectal Cancer

Advanced Science, EarlyView.
T26 is an immunometabolic prodrug that modulates colorectal cancer cells. It blocks glutamine metabolism and enhances STING signaling, which promotes the release of reprogrammed extracellular vesicles. These vesicles drive dendritic cell maturation and CD8⁺ T cell activation, thereby strengthening antitumor immunity and improving the effectiveness of ...
Bingjie Zhang, Renming Fan, Yongrui Hai, Ye Chen, Xintong Lu, Wenhui Wang, Jiarui Dou, Jiaxin Yan, Chang Su, Yue Chen, Le Yang, Minggao Zhao, Lei Liang, Gaofei Wei   +13 more
wiley   +1 more source

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer

Advanced Science, EarlyView.
In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
wiley   +1 more source

Radiographic anatomy of the proximal femur: femoral neck fracture vs. transtrochanteric fracture

Revista Brasileira de Ortopedia
OBJECTIVE: To evaluate the correlation between radiographic parameters of the proximal femur with femoral neck fractures or transtrochanteric fractures.
Ana Lecia Carneiro Leão de Araújo Lima, Saul Caldas Miranda, Hudson Felipe Oliveira de Vasconcelos   +2 more
doaj   +1 more source

Effects of water-based exercise on bone health of middle-aged and older adults:A systematic review and meta-analysis [PDF]

, 2017
Background: Age-related bone loss is a major health concern. Only exercises associated with high-impact and mechanical loading have been linked to a positive effect on bone turnover; however, these types of exercises may not always be appropriate for ...
Climstein, Mike, Hing, Wayne, Pope, Rodney, Simas, Vini   +3 more
core   +1 more source

12‐HETE Is an Endogenous Modulator of BLT2 Triggering Vascular Degeneration, Dissection, and Rupture

Advanced Science, EarlyView.
In thoracic aortic dissection (TAD), elevated levels of the arachidonic acid metabolite 12‐HETE, produced by macrophage‐specific 12/15‐lipoxygenase (12/15‐LOX), bind to the BLT2 receptor on vascular cells. This activates the NOX‐1/ROS/NF‐κB signaling pathway, leading to IL‐6 release.
Yuyu Li, Jiaqi Yu, Weiyao Chen, Xue Wang, Xin Tan, Jing Cui, Yihao Wang, Xuan Xu, Rui Lin, Zhengkai Wang, Wenxi Jiang, Yongliang Zhong, Jie Du, Yuan Wang   +13 more
wiley   +1 more source

Discordance in Bone Mineral Density between the Lumbar Spine and Femoral Neck Is Associated with Renal Dysfunction

, 2022
Seung Eun Lee, Ju‐Hyun Park, Kyoung‐Ah Kim, Han Seok Choi   +3 more
openalex   +1 more source

Capital femoral physeal dysplasia in cats submited to ostectomy of the femoral head and neck [PDF]

, 2021
Tryssia Scalon Magalhães Moi, Marco Aurélio Molina Pires, Kelly Cristiane Ito Yamauchi, Luís Gustavo Gosüen Gonçalves Dias, Bruno Watanabe Minto   +4 more
openalex   +1 more source

Change-of-direction speed and aerobic fitness could influence academy graduation in law enforcement recruit [PDF]

, 2012
BACKGROUND: Technical advancements have produced many challenges to intramedullary implants for unstable pertrochanteric fractures. Helical blade fixation of the femoral head has the theoretical advantages of higher rotational stability and cutout ...
Lockie, Robert G., Balfany, Katherine, Bloodgood, Ashley M., Stierli, Michael, Dulla, Joe, Dawes, Jay, Orr, Rob Marc   +6 more
core   +1 more source

Clinical application of the Femoral Neck System in femoral neck fractures

Asian Journal of Surgery, 2023
Hao Zeng, Xiaobo Yuan, Bo Xiang, Maowen Zheng   +3 more
openaire   +3 more sources

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source