Results 61 to 70 of about 177,321 (324)

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

Fractura por estrés del cuello femoral sobre clavo centromedular en cerrojo [PDF]

, 1994
Se presenta un caso de fractura de estrés del cuello femoral en una paciente de 81 años de edad, a los 7 meses del tratamiento de una fractura de diáfisis femoral mediante clavo intramedular en cerrojo estático.
Albareda Albareda, Jorge Cruz, Palanca Martín, Daniel, Segura Mata, J., Seral Iñigo, Fernando   +3 more
core  

Dietetic care of hip fracture patients across Australia: Are we doing enough? [PDF]

, 2011
Author version made available in accordance with the publisher's policy. This is the peer reviewed version of the following article: Milte R and Miller M, 2011 ‘Dietetic care of hip fracture patients across Australia: Are we doing enough?’ Nutrition and ...
Miller, Michelle Deanne, Milte, Rachel
core   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Valgus osteotomy in delayed presentation of femoral neck fractures using fixed angle simple dynamic hip screw and plate

Chinese Journal of Traumatology, 2019
Purpose: Reduction and fixation in femoral neck fracture in young patients have a problem of nonunion requiring additional procedure like valgus osteotomy but fixation devices are technically difficult for inexperienced surgeons.
Chandrakant Nayak, Biplab Acharyya, Mantu Jain, Kulbhushan Kamboj   +3 more
doaj   +1 more source

Femoroacetabular impingement after the femoral neck fracture healed in a nonanatomical position [PDF]

Vojnosanitetski Pregled, 2019
Introduction. Femoroacetabular impingement is the result of the pathological conditions in the osseous acetabulum and/or the proximal femur. One of its causes is a non-anatomically healed femoral neck fracture. Case report.
Mladenović Marko, Micić Ivan, Milenković Saša, Stojiljković Predrag, Barjaktarović Radoslav   +4 more
doaj   +1 more source

Biomechanical Computed Tomography analysis (BCT) for clinical assessment of osteoporosis. [PDF]

, 2020
The surgeon general of the USA defines osteoporosis as "a skeletal disorder characterized by compromised bone strength, predisposing to an increased risk of fracture." Measuring bone strength, Biomechanical Computed Tomography analysis (BCT), namely ...
Bouxsein, ML, Clarke, BL, Cosman, F, Keaveny, TM, Khosla, S, Orwoll, ES, Siris, ES   +6 more
core  

Femoral Neck Shortening After Hip Fracture Fixation is Associated with Inferior Hip Function: Results from the FAITH Trial.

Journal of Orthopaedics and Trauma, 2019
OBJECTIVE To describe the distribution of femoral neck shortening after internal fixation, and to determine if shortening is associated with inferior hip function at 24-months post-fracture in patients 50 years of age or older.
Jessica E. Felton, G. Slobogean, Sarah S. Jackson, G. D. Della Rocca, S. Liew, R. Haverlag, K. Jeray, S. Sprague, N. O’Hara, M. Swiontkowski, M. Bhandari   +10 more
semanticscholar   +1 more source

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source