Results 191 to 200 of about 43,606 (293)

Senescent BMSC‐Derived Thbs1 Drives Inflammaging and Impairs Bone Regeneration by Suppressing PINK1/Parkin‐Mediated Mitophagy in Macrophages

open access: yesAging Cell, Volume 25, Issue 6, June 2026.
Aging BMSC‐derived Thbs1 activates the macrophage TGF‐β/Smad3 pathway to transcriptionally repress Pink1, impairing mitophagy and causing mitochondrial ROS accumulation. This redox imbalance drives M1 polarization and IL‐6 secretion. IL‐6 feeds back to BMSCs via the JAK/STAT3 pathway to inhibit osteogenesis and upregulate Thbs1, establishing a self ...
Yifeng Xing   +15 more
wiley   +1 more source

Aging‐Related Muscle Bmal1 Decline Contributes to Bone Loss in Mice via Enhancing IL‐1α–Mediated Osteoclastogenesis

open access: yesAging Cell, Volume 25, Issue 6, June 2026.
Aging‐related decline of muscle Bmal1 drives bone loss in mice by disrupting Hmox1 and increasing IL‐1α, which promotes osteoclast activity. Time‐restricted feeding reestablishes diurnal Hmox1 expression, reduces IL‐1α, and alleviates osteoporosis, offering a potential therapeutic strategy. ABSTRACT Osteoporosis, a common metabolic bone disorder linked
Kai Huang   +5 more
wiley   +1 more source

Tissue‐retained needles in people who inject drugs: A systematic review of case reports and series on clinical presentations, complications and management

open access: yesAddiction, Volume 121, Issue 6, Page 1381-1397, June 2026.
Abstract Background and aims Tissue‐retained needles from intravenous drug use can cause rare but severe complications, ranging from local to systemic infections to needle embolization. Due to the limited evidence and the lack of epidemiological studies on the issue, we systematically reviewed the literature focusing on case reports and case series on ...
Heidi Laukkala   +7 more
wiley   +1 more source

Femoral Neck Fractures, the Unsolved Enigma: Where Error is Costly, and Preservation is Priceless. [PDF]

open access: yesJ Orthop Case Rep
Dheenadhayalan J   +3 more
europepmc   +1 more source

Recognising disease progression in MGUS and smouldering myeloma: Biomarkers, symptom monitoring and imaging

open access: yesBritish Journal of Haematology, Volume 208, Issue 6, Page 2079-2086, June 2026.
Summary The Tackling Early Morbidity and Mortality in Myeloma trial (TEAMM) trial recruited 977 newly diagnosed myeloma patients from 93 UK hospitals to assess the advantages and disadvantages of prophylactic antibiotics for the first 12 weeks. This paper analyses the 133 (14%) patients who had previously known precursor disease including monoclonal ...
Aidan Haslam   +9 more
wiley   +1 more source

Digital Surveillance After Allogeneic Hematopoietic Stem Cell Transplantation Guides Therapeutic Interventions to Reduce Non‐Relapse Mortality

open access: yesEuropean Journal of Haematology, Volume 116, Issue 6, Page 937-942, June 2026.
ABSTRACT Introduction Allogeneic hematopoietic stem cell transplantation (HSCT) offers curative potential for many hematological malignancies; however, outcomes may be adversely affected by infections and transplant‐associated complications, contributing to non‐relapse mortality (NRM).
Lara Bischof   +17 more
wiley   +1 more source

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