Results 201 to 210 of about 83,212 (276)

AMSC‐sEVs Ameliorated Crohn's Disease by Inhibiting Macrophage‐Myofibroblast Transition Through the Delivery of MFGE8

open access: yesCell Proliferation, EarlyView.
Our study demonstrated that TGF‐β1 activated MAPK signalling pathway and promoted the MMT and secretion of CCL17 under CD‐associated intestinal inflammatory conditions. AMSC‐sEVs can deliver MFGE8, which inhibits MMT and CCL17‐mediated Treg recruitment by suppressing the MAPK signalling pathway, thereby alleviating intestinal fibrosis.
Minghao Xie   +6 more
wiley   +1 more source

CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis

open access: yesCell Proliferation, EarlyView.
CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng   +12 more
wiley   +1 more source

Systematic screening for age‐related comorbidities: Health care optimization among persons with HIV in an outpatient setting

open access: yesHIV Medicine, EarlyView.
Abstract Background Age‐related comorbidities occur earlier and more frequently in people with HIV (PWH) than in the general population and have emerged as a key challenge in long‐term HIV care. Unfortunately, many of these conditions remain undiagnosed, and systematic screening in clinical practice remains limited.
Anna Katrine Haslund Roed   +4 more
wiley   +1 more source

Bone health in adults with non‐ambulatory neuromuscular disorders: scoping review of risk factors, diagnosis and management

open access: yesInternal Medicine Journal, EarlyView.
Abstract Background Non‐ambulatory adults have an increased risk of osteoporosis and fractures due to reduced weight‐bearing and diminished neuromuscular stimulation, resulting in substantial morbidity and mortality. Aims This scoping review aimed to systematically evaluate risk factors, diagnostic indicators and management strategies for optimising ...
Thomas Bailey   +4 more
wiley   +1 more source

AI‐enhanced decision support for fall patients: streamlining inpatient flow in the emergency department

open access: yesInternational Transactions in Operational Research, EarlyView.
Abstract Emergency department (ED) overcrowding and inefficient patient flow are significant operational challenges, often amplified by the volume of patients sustaining fall‐related injuries. This study predicts hospital admission for these encounters by leveraging unstructured clinical text: triage chief complaints (reasons for seeking care) and ...
Dinesh R. Pai   +2 more
wiley   +1 more source

Variation in trabecular bone microarchitecture across rhesus macaque (Macaca mulatta) load‐bearing joints

open access: yesJournal of Anatomy, EarlyView.
Aging of bone density (BV/TV) is regional: Forelimb [left] elements gain bone sporadically (orange) but hind limb elements [right] lose bone globally (blue). Abstract Globally, human population structure is quickly trending older, increasing the prevalence and systemic burden of age‐related skeletal disorders such as osteoporosis.
Cassandra M. Turcotte   +16 more
wiley   +1 more source

Postcranial anatomy of the Miocene hippopotamoids of Toros‐Menalla, Chad

open access: yesJournal of Anatomy, EarlyView.
We establish a framework for the identification of postcranial remains in hippopotamoids by describing and comparing for the first time two late Miocene hippopotamoids from Toros‐Menalla, Chad (Hexaprotodon garyam, an early hippopotamid, and Libycosaurus bahri, the last African anthracothere) with the common hippopotamus.
Lorenzo Scribano   +4 more
wiley   +1 more source

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