Results 241 to 250 of about 93,984 (297)

Locomotor muscle dysfunction and rehabilitative exercise training in fibrotic interstitial lung disease: Where are we at and where could we go?

open access: yesExperimental Physiology, EarlyView.
Abstract Exercise limitation is a cardinal feature of fibrotic interstitial lung disease arising from pulmonary gas exchange, respiratory mechanical and cardio‐circulatory abnormalities. More recently, it has been recognized that impairment in locomotor muscle function (e.g., reduced muscle mass/strength or heightened fatigability) might also play a ...
Sarah Thivent   +7 more
wiley   +1 more source

Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI

open access: yesExperimental Physiology, EarlyView.
Abstract Human cerebrovasculature is finely tuned to enable local changes in blood flow to meet the brain's demands, whilst protecting the brain from systemic changes in blood pressure, both acutely during a heartbeat and chronically over time. This review summarises cerebrovascular structure and function, their role in disease and neurodegeneration ...
Ian D. Driver, Kevin Murphy
wiley   +1 more source

TRPV1 blockade restores the baroreflex control of renal sympathetic nerve activity in cisplatin‐induced renal injury in rats

open access: yesExperimental Physiology, EarlyView.
Abstract Renal injury is associated with inflammatory responses within the kidney which could involve activation of transient receptor potential vanilloid 1 (TRPV1) channels. This study investigated whether TRPV1 channels modulate baroreflex regulation of renal sympathetic nerve activity (RSNA) in a rat model of cisplatin‐mediated renal injury.
Mohammed H. Abdulla   +3 more
wiley   +1 more source

Persistence of fatigue in the absence of pathophysiological mechanisms in some patients more than 2 years after the original SARS‐CoV‐2 infection

open access: yesExperimental Physiology, EarlyView.
Abstract Following an acute infection with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a substantial percentage of patients report the persistence of debilitating symptoms, often grouped in a syndrome termed ‘long COVID’. We sought to identify potential pathophysiological mechanisms responsible for the persistence, in some long COVID ...
Giovanni Baldassarre   +10 more
wiley   +1 more source

Ageing attenuates regional vasoconstriction during acute lowering of upper and lower limbs

open access: yesExperimental Physiology, EarlyView.
Abstract The venoarteriolar and myogenic response (VMR) is a non‐adrenergic, non‐baroreflex‐mediated mechanism that increases local vascular resistance and contributes to blood pressure (BP) regulation during orthostasis. Despite the importance of the VMR in human cardiovascular control, no information exists elucidating possible differences in the VMR
John D. Akins   +10 more
wiley   +1 more source

Ageing exacerbates the adverse effects of respiratory muscle fatigue on vascular function, locomotor muscle fatigue and exercise performance in males

open access: yesExperimental Physiology, EarlyView.
Abstract This study investigated the effect of respiratory muscle fatigue on cardiovascular function, locomotor muscle fatigue and exercise performance in young and master athletes, a model of successful ageing. Ten young male (YA, 27.4 ± 4.4 years) and 11 male master endurance athletes (MA, 65.0 ± 5.1 years) performed, on separate days, two constant ...
Valentin Mons   +4 more
wiley   +1 more source

Differential contribution of T‐type voltage‐gated calcium channels to vascular reactivity in the aorta and renal artery of healthy rabbits

open access: yesExperimental Physiology, EarlyView.
Abstract figure T‐type VGCCs contribute to the contraction of the rabbit aorta and modulate both contraction and vasodilation in the rabbit renal artery. α1, alpha 1 adrenergic receptor; ATR, angiotensin II receptor; Ang II, angiotensin II; CaM, calmodulin; Cav3, T‐type voltage‐gated Ca2⁺ channels; cGMP, cyclic guanidine monophosphate; EC, endothelial ...
Andrea Suarez   +6 more
wiley   +1 more source

Exploring neuronal mechanisms of osteosarcopenia in older adults

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The mechanosensitive osteocytic network within the bone matrix acts as a receptor and plays a crucial role in the functional adaptation of bone to mechanical loading. Through mechanotransduction, osteocytes convert mechanical impulses into electrical signals, which are transmitted via afferent nerves to sympathetic preganglionic ...
Ilhan Karacan, Kemal Sıtkı Türker
wiley   +1 more source

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