Results 251 to 260 of about 93,984 (297)

Electrical stimulation of injured nerves promotes recovery in animals and humans

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Poor functional recovery after surgical repair is frequently disappointing. In an experimental rat model, we found that by isolating the effects of prolonged motoneurone isolation from targets (prolonged axotomy), reduced regenerative capacity and prolonged isograft denervation, and muscle denervation each reduced regeneration ...
Tessa Gordon
wiley   +1 more source

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker   +2 more
wiley   +1 more source

The contribution of age and sex hormones to female neuromuscular function across the adult lifespan

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend This study mapped the age‐related trajectory of neuromuscular deterioration in 88 healthy females aged 18–80 years old. An accelerated reduction in neuromuscular function, primarily of peripheral muscular origin, coincided with the age of menopause onset.
Steven J. O'Bryan   +4 more
wiley   +1 more source

Neuromuscular junction instability with inactivity: morphological and functional changes after 10 days of bed rest in older adults

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend This figure summarises the study of neuromuscular junction (NMJ) changes in 10 older males following a 10 day bed rest period. Baseline (BR0) and post‐bed rest (BR10) assessments were conducted using intramuscular EMG (iEMG) to measure NMJ transmission. At BR0 and BR10, muscle biopsies were obtained to analyse NMJ morphology, and
Evgeniia Motanova   +10 more
wiley   +1 more source

Antenatal melatonin for cardiovascular deficits in fetal growth restriction

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend This study used an ovine model of fetal growth restriction (FGR) to investigate the potential cardioprotective effects of melatonin (MLT) in postnatal growth‐restricted lambs. We demonstrated that, while peripheral endothelial function progressively declines between birth and 4 weeks in FGR lambs, FGR+MLT lambs exhibit impaired ...
Charmaine R. Rock   +9 more
wiley   +1 more source

Acid‐sensing ion channel 1a deficiency drives endocrine hypertension in male mice

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Acid‐sensing ion channel 1a deficiency drives endocrine hypertension in aged male mice. Global deletion of ASIC1a (Asic1a−/−) in adult male mice (6 months old) elevates corticosterone, leading to hypokalaemia, volume expansion, increased pulse pressure and cardiomyocyte hypertrophy.
Selina M. Garcia   +9 more
wiley   +1 more source

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