Results 271 to 280 of about 476,865 (415)

Targeting PFKFB4 Biomimetic Codelivery System Synergistically Enhances Ferroptosis to Suppress Small Cell Lung Cancer and Augments the Efficacy of Anti‐PD‐L1 Immunotherapy

Advanced Science, EarlyView.
In this study, a targeting PFKFB4 biomimetic codelivery system is developed to improve paclitaxel efficacy by inducing ferroptosis in SCLC. This system enhances immune cell infiltration and cytokine secretion, activating anti‐tumor immunity. Combined with anti‐PD‐L1, it boosts immune responses, offering a novel therapeutic strategy for overcoming ...
Xiang Liu, Jingjun He, Haoxuan Ying, Cuiying Chen, Chongyang Zheng, Peng Luo, Weiliang Zhu, Ting Wei, Bufu Tang, Jian Zhang   +9 more
wiley   +1 more source

Ambulatory children with spastic cerebral palsy have smaller bone area and deficits in trabecular microarchitecture. [PDF]

J Bone Miner Res
Zimmermann EA, Veilleux LN, Gagnon M, Audet D, Yap R, Julien C, Hosseinitabatabaei S, Rioux Trottier E, Willie BM, Carriero A, Farmer JP.   +10 more
europepmc   +1 more source

THE CONTROL OF THE UPPER FRAGMENT IN HIGH FRACTURES OF FEMUR AND HUMERUS BY A NEW FORM OF PELVIC-FEMUR SPLINT AND ARM SPLINT. [PDF]

, 1919
JohnRobert Lee
openalex   +1 more source

Total Femur Replacement After Tumor Resection: Limb Salvage Usually Achieved But Complications and Failures are Common

Clinical Orthopaedics and Related Research, 2015
F. Sevelda, R. Schuh, J. Hofstaetter, M. Schinhan, R. Windhager, P. Funovics   +5 more
semanticscholar   +1 more source

LncRNA‐MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid–Liquid Phase Separation

Advanced Science, EarlyView.
This study has identified lncRNA‐MEG3 as a key regulator of muscle mass, promoting slow‐twitch muscle fibers and preventing muscle atrophy. By stabilizing the SUZ12/PRC2 complex through liquid–liquid phase separation (LLPS), lncRNA‐MEG3 influences mitochondrial function and lipid metabolism.
Yilong Yao, Chao Yan, Haibo Huang, Shilong Wang, Jiaying Li, Yun Chen, Xiaolu Qu, Qi Bao, Lingna Xu, Yuanyuan Zhang, Danyang Fan, Xia He, Yanwen Liu, Yongsheng Zhang, Yalan Yang, Zhonglin Tang   +15 more
wiley   +1 more source

Metabolic rewiring caused by mitochondrial dysfunction promotes mTORC1-dependent skeletal aging. [PDF]

Sci Adv
Bubb K, Etich J, Probst K, Parashar T, Schuetter M, Dethloff F, Reincke S, Nolte JL, Krüger M, Schlötzer-Schrehard U, Nüchel J, Demetriades C, Giavalisco P, Riemer J, Brachvogel B.   +14 more
europepmc   +1 more source

ON THE TREATMENT OF THE SEPARATION OF THE LOWER EPIPHYSIS OF THE FEMUR

, 1929
Ernst Gold
openalex   +2 more sources

REMOVAL OF THE BREAST, FOLLOWED BY SPONTANEOUS FRACTURE OF THE FEMUR. [PDF]

, 1883
John Hamilton
openalex   +1 more source

Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
The gut microbiome is a potential target for treating cardiovascular disease. It is found that prophylactic administration of Flavonifractor plautii or its metabolite desaminotyrosine (DAT) exerts pleiotropic cardioprotective effects via promoting cardiomyocyte survival and attenuating cardiac inflammation against myocardial ischemia/reperfusion (I/R ...
Heng Du, Xu Liu, Jianghua Shen, Hailong Yuan, Hao Zhang, Gan Xi, Yujing Li, Yuhan Wang, Jiahe Zhang, Chaofan Yang, Pengfei Xu, Jiawan Wang, Fang Wang, Siqi Liu, Yanan Zhou, Qi Gu, Jingjing Lu, Tuo Wei, Zeyu Gao, Jingyi Zang, Jun Wang, Moshi Song   +21 more
wiley   +1 more source

New information on the Hind limb feathering, soft tissues and skeleton of Microraptor (Theropoda: Dromaeosauridae). [PDF]

BMC Ecol Evol
Chotard M, Wang X, Zheng X, Kaye TG, Grosmougin M, Barlow L, Kundrát M, Dececchi TA, Habib MB, Zariwala J, Hartman S, Xu X, Pittman M.   +12 more
europepmc   +1 more source