Results 41 to 50 of about 187,799 (323)

A multiscale mechanobiological model of bone remodelling predicts site-specific bone loss in the femur during osteoporosis and mechanical disuse [PDF]

Biomech. Model. Mechanobiol. (2016) 15:43-67, 2015
We propose a multiscale mechanobiological model of bone remodelling to investigate the site-specific evolution of bone volume fraction across the midshaft of a femur. The model includes hormonal regulation and biochemical coupling of bone cell populations, the influence of the microstructure on bone turnover rate, and mechanical adaptation of the ...
arxiv   +1 more source

Femur fractures in infants.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2008
The Red Cross War Memorial Children’s Hospital trauma unit manages approximately 10 000 children under the age of 12 years annually. Approximately 500 (5%) have non-accidental causes which can further be divided into Sexual Abuse (approximately 150; 1.5%) and Physical Abuse cases (approximately 350; 3.5%).
van As, Arjan Bastiaan, Garach, Sharadh
openaire   +5 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Periosteal osteoid osteoma of the distal femur

Orthopedic Reviews, 2010
Periosteal osteoid osteoma is extremely rare. The diagnosis is not always clear. We report a case of periosteal osteoid osteoma arising from the posterior surface of the right distal femur in a 21-year-old woman.
Mohammed Fahd Amar, Salma Almoubaker, Badr Chbani, Sanae Chahbouni, Amine Marzouki, Afaf Amarti, Fawzi Boutayeb   +6 more
doaj   +1 more source

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

FEBS Open Bio, EarlyView.
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang, Yukun Xu, Yujia Li, Yiming Pang, Xueting Ding, Raorao Zhou, Dan Liang, Xianda Che, Yuanyu Zhang, Chunfang Wang, Wenjin Li, Pengcui Li   +11 more
wiley   +1 more source

Multi-Task Learning Approach for Unified Biometric Estimation from Fetal Ultrasound Anomaly Scans [PDF]

arXiv, 2023
Precise estimation of fetal biometry parameters from ultrasound images is vital for evaluating fetal growth, monitoring health, and identifying potential complications reliably. However, the automated computerized segmentation of the fetal head, abdomen, and femur from ultrasound images, along with the subsequent measurement of fetal biometrics ...
arxiv  

Surgical Classification for Preclinical Rat Femoral Bone Defect Model: Standardization Based on Systematic Review, Anatomical Analysis and Virtual Surgery

Bioengineering, 2022
Though surgical techniques profoundly influence in vivo experiments, significant heterogeneity exists in current surgeries for inducing rat femoral bone defects. Such variations reduce the reproducibility and comparability of preclinical studies, and are
Yu Sun, Heike Helmholz, Regine Willumeit-Römer   +2 more
doaj   +1 more source

A Deep Learning-Based Method for Automatic Segmentation of Proximal Femur from Quantitative Computed Tomography Images [PDF]

arXiv, 2020
Purpose: Proximal femur image analyses based on quantitative computed tomography (QCT) provide a method to quantify the bone density and evaluate osteoporosis and risk of fracture. We aim to develop a deep-learning-based method for automatic proximal femur segmentation.
arxiv  

Segmentation of the Proximal Femur from MR Images using Deep Convolutional Neural Networks [PDF]

Scientific Reports, volume 8, Article number: 16485 (2018), 2017
Magnetic resonance imaging (MRI) has been proposed as a complimentary method to measure bone quality and assess fracture risk. However, manual segmentation of MR images of bone is time-consuming, limiting the use of MRI measurements in the clinical practice. The purpose of this paper is to present an automatic proximal femur segmentation method that is
arxiv   +1 more source

FRACTURES OF THE FEMUR

Annals of Surgery, 1916
This paper will treat the subject of simple fractures of the shaft of the femur in a general manner, laying down the principles applicable to the management of fractures in the several regions of the bone, or divisions ordinarily designated in the study and treatment of fractures of the femur.
openaire   +4 more sources