Results 251 to 260 of about 1,725,891 (346)

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

open access: yesMed Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin   +8 more
wiley   +1 more source

Optimized analytical segmented method for improved intravoxel incoherent motion parameter extraction in low‐perfused tissues

open access: yesMagnetic Resonance in Medicine, EarlyView.
Abstract Purpose Intravoxel incoherent motion (IVIM) diffusion‐weighted imaging of tissue perfusion and diffusion has limited signal in low‐perfused tissues, which poses a challenge in measuring IVIM parameters. This work proposes an optimized analytical segmented (opAS) method for extracting IVIM parameters and compares its performance with prior ...
Erick O. Buko   +2 more
wiley   +1 more source

Digitally Designed Bone; A 3D-patient-specific Allograft Shelf for Severe Adolescent Hip Dysplasia: From Digital Design to Clinical Reality-A Conceptual Case Report. [PDF]

open access: yesJ Am Acad Orthop Surg Glob Res Rev
van Bussel EM   +10 more
europepmc   +1 more source

Quantitative macromolecular proton fraction imaging using pulsed spin‐lock

open access: yesMagnetic Resonance in Medicine, EarlyView.
Abstract Purpose Recent studies have shown that spin‐lock MRI can simplify quantitative magnetization transfer (MT) by eliminating its dependency on water pool parameters, removing the need for a T1 map in macromolecular proton fraction (MPF) quantification. However, its application is often limited by the requirement for long radiofrequency (RF) pulse
Qianxue Shan   +7 more
wiley   +1 more source

Utilizing 3D fast spin echo anatomical imaging to reduce the number of contrast preparations in T1ρ$$ {T}_{1\rho } $$ quantification of knee cartilage using learning‐based methods

open access: yesMagnetic Resonance in Medicine, EarlyView.
Abstract Purpose To propose and evaluate an accelerated T1ρ$$ {T}_{1\rho } $$ quantification method that combines T1ρ$$ {T}_{1\rho } $$‐weighted fast spin echo (FSE) images and proton density (PD)‐weighted anatomical FSE images, leveraging deep learning models for T1ρ$$ {T}_{1\rho } $$ mapping. The goal is to reduce scan time and facilitate integration
Junru Zhong   +10 more
wiley   +1 more source

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