Results 51 to 60 of about 62,996 (256)

Bilateral Femoral Head Insufficiency Fractures and Multiple Vertebral Fractures: A Case Report on Rare Presentations of Pregnancy and Lactation-associated Osteoporosis and Their Outcomes

Türk Osteoporoz Dergisi, 2020
Pregnancy and lactation-associated osteoporosis (PLO) is a rare condition seen in the last trimester of pregnancy and early puerperal period which can result in vertebral and femoral fractures. In this case report, two cases of fractures secondary to PLO,
Selin Özen, Oya Ümit Yemişci, Seyhan Sözay   +2 more
doaj   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

A Dual‐Phase Exosomal Nanotherapy Enhances Continual Efferocytosis by Coordinating Checkpoint Inhibition and Metabolic Reprogramming in Atherosclerosis

Advanced Science, EarlyView.
Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng, Shiteng Cai, Jinfeng Gao, Sheng Zhao, Bohan Wei, Xueyi Weng, Zhengmin Wang, Qiaozi Wang, Qiyu Li, Chengzhi Han, Weiyan Li, Yiwen Tan, Yuyuan Fu, Meng Ji, Zheyong Huang, Yanan Song, Juying Qian, Junbo Ge   +17 more
wiley   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Microrobotic Catheterization of the Ophthalmic Artery for Targeted Treatment of Retinoblastoma

Advanced Intelligent Systems, EarlyView.
A microrobotic platform is presented that allows teleoperated and autonomous navigation of flow‐driven magnetic microcatheters, MagFlow, into the ophthalmic artery for superselective intra‐arterial infusion of chemotherapy to treat retinoblastoma. Extensive benchtop validations with patient‐derived biomimetic phantoms under optical and fluoroscopic ...
Artur Banach, Mehdi Krichen, Julian Raub, Christina Stathopoulos, Bruno Bartolini, Mahmut Selman Sakar   +5 more
wiley   +1 more source

CT-Based Evaluation of Bone Mineral Density Distribution of Proximal Femur in Patients With Femoral Trochanteric Fracture

Geriatric Orthopaedic Surgery & Rehabilitation
Background Surgical treatment of proximal femoral fractures typically involves fixation with intramedullary nailing or sliding hip screws, where screws inserted into the femoral head stabilize the fracture site.
Daisuke Enomoto MD, Hyonmin Choe MD, PhD, Masahiro Matsumoto MD, Koki Abe MD, PhD, Kazuyoshi Yamamoto MD, PhD, Kousuke Matsuo MD, PhD, Hiroyuki Makita MD, PhD, Naomi Kobayashi MD, PhD, Yutaka Inaba MD, PhD   +8 more
doaj   +1 more source

Prosthesis Design and Stress Profile after Hip Resurfacing: A Finite Element Analysis

Journal of Orthopaedic Surgery, 2008
Purpose. To evaluate the effect of prosthesis design on stress profile in the proximal femur after hip resurfacing. Methods. The von Mises stress profile of the native femur was simulated and compared with that of resurfaced femurs using various ...
A Heijink, ME Zobitz, R Nuyts, BF Morrey, KN An   +4 more
doaj   +1 more source

FEMORAL HEAD OSTECTOMY IN A DOG SUFFERING FROM HIP DYSPLASIA [PDF]

Exploratory Animal and Medical Research, 2020
Femoral Head Ostectomy (FHO) is the surgical removal of head and neck of femur. A nine-month-old dog was reported with complaint of lameness. On clinical and radiographic examination, it was diagnosed as hip dysplasia of right hip joint.
Ram Najar Chaudhary, Ram Niwas, Sandeep Kumar   +2 more
doaj  

PUS7 Deficiency: Phenotypical Expansion of PUS7‐Related Neurodevelopmental Disorders

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Pathogenic variants in PUS7, encoding pseudouridine synthase 7, cause a rare neurodevelopmental disorder marked by intellectual disability, microcephaly, short stature, and behavioral disturbances. Since the first report in 2018, only 16 patients have been described.
Alice Muda, Barbara Belmessieri, Patrizia Accorsi, Jessica Galli, Edoardo Errichiello, Lucio Giordano   +5 more
wiley   +1 more source

Prenatal Evaluation of RNU4‐2 Variants in Fetuses With Central Nervous System Anomalies

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Fetal central nervous system (CNS) anomalies are among the most common congenital malformations, yet the overall prenatal diagnostic yield of current genetic testing remains below 40%. Variants in RNU4‐2, a non‐coding gene encoding the U4 small nuclear RNA (snRNA), have recently been linked to a novel highly recurrent dominant ...
Yiyao Chen, Li Gao, Xu Han, Yunyun Cao, Lanlan Zhang, Yi Wu, Xinrong Zhao, Wenjing Hu, Ruiyu Ma, Renyi Hua, Niu Li, Yanlin Wang, Jian Wang, Shuyuan Li   +13 more
wiley   +1 more source