Results 51 to 60 of about 1,305,072 (296)

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Partial femoral head replacement: a new innovative hip-preserving approach for treating osteonecrosis of the femoral head and its finite element analysis

Frontiers in Bioengineering and Biotechnology
Purpose: Controversy remains regarding the optimal treatment for stage III Osteonecrosis of the femoral head (ONFH). This study presents, for the first time, the precise treatment of stage III ONFH using the “substitute the beam for a pillar” technique ...
Yanjiang Yang, Yanjiang Yang, Yanjiang Yang, Xiaodong Cheng, Xiaodong Cheng, Xiaodong Cheng, Wei Chen, Wei Chen, Wei Chen, Guimiao Li, Guimiao Li, Guimiao Li, Yuchuan Wang, Yuchuan Wang, Yuchuan Wang, Weiyi Sun, Weiyi Sun, Weiyi Sun, Wen An, Wen An, Wen An, Qi Zhang, Qi Zhang, Qi Zhang, Yingze Zhang, Yingze Zhang, Yingze Zhang, Yingze Zhang, Yingze Zhang   +28 more
doaj   +1 more source

Development of a test system to analyze different hip fracture osteosyntheses under simulated walking [PDF]

, 2012
The mechanical complications of osteosyntheses after hip fractures are previously investigated by mostly static or dynamic uniaxial loading test systems.
Lenich, Andreas, Dendorfer, Sebastian, Füchtmeier, Bernd, Bachmeier, Samuel, Mayr, Edgar, Nerlich, Michael, Bachmeier, S., Mayr, E., Lenich, A;Bachmeier, S;Dendorfer, S;Mayr, E;Nerlich, M;Füchtmeier, B   +8 more
core   +1 more source

Rocket‐Inspired Sequentially Targeted Nanotherapeutics for Mitochondrial Regulation and Inflammatory Reprogramming in Ischemic Stroke

Advanced Science, EarlyView.
A novel neutrophil‐hitchhiking, rocket‐inspired nanoplatform is developed to cross the blood‐brain barrier for sequential, spatiotemporal drug delivery. By responsive surface transformation in the ischemic penumbra, it precisely targets mitochondria to suppress Drp1‐mediated fission.
He Bai, Zihao Yong, Yang Li, Qingmin Chen, Yong Liu, Xiaomeng Guo, Fukai Li, Shicheng Tang, Zhuo Yang, Yufei Zhang, Ruwei Jie, Xiaohong Lv, Huacheng Wang, Chunming Huang, Liwei Xie, Jianqi Xiao, Qingchun Mu, Longguang Tang   +17 more
wiley   +1 more source

MORPHOMETRIC STUDY OF THE DRY FEMUR IN SOUTH GUJARAT POPULATION

National Journal of Medical Research, 2020
Introduction: Femur is the longest and strongest bone of the body located within thigh extending from hip to knee. In upright posture, it transmits the body weight from hip to knee.
Vipul D Patel, Rashvaita K Patel
doaj  

Differential Tissue‐Coupled Powering for Battery‐Free Injectable Electroceuticals

Advanced Science, EarlyView.
A thread‐like injectable neural stimulator is powered through differential tissue‐coupled powering (DTCP), which harvests RF‐frequency tissue potentials with an elongated receiver while preserving a injectable cross‐section. The system integrates an ASIC, stimulation electrodes, and a portable transmitter, enabling wireless peripheral nerve stimulation,
Han Wu, Sultan Mahmud, Mali Halac, Asif Iftekhar Omi, Domenica Sofia Baez Rodas, Jeremiasz Dados, Chaojun Cheng, Anyu Jiang, Cameron Wallace, Anvi Singh, Erin Patrick, Baibhab Chatterjee, Shriya Srinivasan, Adam Khalifa   +13 more
wiley   +1 more source

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

Transient 18F-Fluorodeoxyglucose Activity on PET/CT of Herniation Pit in Thyroid Cancer Patient: A Case Report

대한영상의학회지, 2017
A herniation pit is a benign bone pit characterized by its femoral location and surrounding sclerotic margin. Few reports have been issued on the fluorodeoxyglucose (FDG) positron emission tomography findings of herniation pit.
Yun Hee Kang, Geon Park
doaj   +1 more source

Outcome of bone marrow instillation at fracture site in intracapsular fracture of femoral neck treated by head preserving surgery

Chinese Journal of Traumatology, 2017
Purpose: The aim of present study is to evaluate the outcome of bone marrow instillation at the fracture site in fracture of intracapsular neck femur treated by head preserving surgery.
Nikhil Verma, M.P. Singh, Rehan Ul-Haq, Rajesh K. Rajnish, Rahul Anshuman   +4 more
doaj   +1 more source

Dose-dependent new bone formation by extracorporeal shock wave application on the intact femur of rabbits [PDF]

, 2008
Background: Whereas various molecular working mechanisms of shock waves have been demonstrated, no study has assessed in detail the influence of varying energy flux densities (EFD) on new bone formation in vivo. Methods: Thirty Chinchilla bastard rabbits
S. Milz, J. Hausdorf, Tischer, T., Milz, S., C. Pautke, T. Tischer, C. Schmitz, C. Weiler, Pautke, C., Weiler, C., Maier, M., M. Maier, Hausdorf, J., Schmitz, C., Tischer, T.;Milz, S.;Weiler, C.;Pautke, C.;Hausdorf, J.;Schmitz, C.;Maier, M., Tischer, T;Milz, S;Weiler, C;Pautke, C;Hausdorf, J;Schmitz, C;Maier, M   +15 more
core   +1 more source