Results 111 to 120 of about 761,624 (385)

Reproducibilty of partial weight bearing [PDF]

Objectives: To find out whether partial weight bearing can be reproduced and retained. Design: In vivo experiment in normal subjects. Intervention: Training for partial weight bearing (25% of body weight) using bathroom scales.
Doyle, J, Jones, R K, Malviya, A, Richards, Jim, Udwadia, A   +4 more
core   +1 more source

Femoral Nerve Block Intervention in Neck of Femur Fracture (FINOF): a randomized controlled trial [PDF]

, 2018
Objective Fractured neck of femur is a severely painful condition with significant mortality and morbidity. We investigated whether early and continuous use of femoral nerve block can improve pain on movement and mobility after surgery in older ...
Armstrong, Sarah, Bedforth, Nigel M., Bradley, Jim, Mannings, Alexa, Moppett, Iain K., Rowlands, Martin, Sahota, Opinder, Walt, Gerrie van de   +7 more
core   +2 more sources

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Compression or tension? The stress distribution in the proximal femur [PDF]

, 2017
Comparative StudyEvaluation StudiesThis is the final version of the article. Available from BioMed Central via the DOI in this record.BACKGROUND: Questions regarding the distribution of stress in the proximal human femur have never been adequately ...
Aspden, RM, Meakin, JR, Rudman, KE
core   +1 more source

Nasal Mucosa‐Derived Extracellular Vesicles as a Systemic Antiaging Intervention

Advanced Science, EarlyView.
This study shows that nasal mucosa‐derived extracellular vesicles (nmEVs) exert systemic anti‐ageing effects in mice by restoring circadian rhythm, suppressing cellular senescence, and improving cognitive function. In aged human bone marrow mesenchymal stem cells, nmEVs reverse senescence‐associated phenotypes and reactivate core clock gene expression.
Wentao Shi, Lu Bian, Mengyuan Yu, Jun Wang, Mingzhu Gao, Liping Shen, Xiao Zhang, Zhiliang Huang, Hong Tang, Long Lv, Yunduan Que, Zengli Miao, Xuechao Wu, Qing Wang, Xiaojie Lu   +14 more
wiley   +1 more source

"Neglected neck of femur fracture: Valgus intertrochanteric osteotomy, rigid internal fixation and cortical bone grafting": Forgotten but useful technique

Journal of Orthopedics, Traumatology and Rehabilitation, 2014
Nonunion of fracture neck of femur is still a formidable surgical challenge. We hereby report a case of 23-year-old male who presented to us 6 years after trauma with a fracture neck of the femur with 7 cm shortening. In view of his young age, we treated
Mohan K Puttaswamy, Mukkanna Kudapalli
doaj   +1 more source

The Auditory System of the Dipteran Parasitoid Emblemasoma auditrix (Sarcophagidae) [PDF]

, 2016
Several taxa of insects evolved a tympanate ear at different body positions, whereby the ear is composed of common parts: a scolopidial sense organ, a tracheal air space, and a tympanal membrane. Here, we analyzed the anatomy and physiology of the ear at
Kampschulte, Marian, Lakes-Harlan, Reinhard, Martels, Gunhild, Stumpner, Andreas, Stölting, Heiko, Tron, Nanina   +5 more
core   +1 more source

Designer Solid Self‐Emulsifying Nanovaccines Enable Dual Modulation of Dendritic Cells and T Cells for Potent Antitumor Immunity

Advanced Science, EarlyView.
A solid self‐emulsifying (SSE) platform is loaded with peptide antigens and CpG to form the SSE vaccine. An ApoE‐enriched corona promotes dendritic cell internalization, enabling antigen presentation and T cell activation. Squalene from the SSE also sensitizes T cells by promoting lipid raft formation.
Xueying Shen, Shiqi Fan, Jia He, Lanqing Luo, Junyao Li, Chengcheng Wu, Kairu Yang, Xiaojun Xia, Rui Kuai   +8 more
wiley   +1 more source

Neck of Femur Fracture among Senior Citizen Managed with Hemiarthroplasty in a Tertiary Care Center in Nepal: An Observational Study

Journal of Nepal Medical Association
Introduction: Hemiarthroplasty is recognized as a prominent therapeutic option for neck of femur fracture without preexisting acetabular  pathology; however, there are controversies in the scientific literature regarding this.
Bijay Poudel, Rohit Shrestha, Bhaskar Raj Karki, Ashkal Basi, Sushant Kumar Khadka, Aashutosh Chaudhary, Amartya Dahal, Shreejana Pandey, Darshan Gopal Dhoju   +8 more
doaj   +1 more source

National trends in total hip arthroplasty for traumatic hip fractures: An analysis of a nationwide all-payer database. [PDF]

, 2020
BACKGROUND: Hemiarthroplasty (HA) has traditionally been the treatment of choice for elderly patients with displaced femoral neck fractures. Ideal treatment for younger, ambulatory patients is not as clear.
Boniello, Anthony J, Cavanaugh, Priscilla, Denehy, Kevin, Kerbel, Yehuda E, Lieber, Alexander M, Star, Andrew   +5 more
core   +1 more source