Results 231 to 240 of about 702,880 (318)

The central collinear start point in femoral reconstruction nailing decreases ultimate failure load of the femoral neck: a cadaveric biomechanics study. [PDF]

OTA Int
Lee RC, Voinier SD, McCarthy CF, Vyas HK, Khan UA, Harrington CJ, Helgeson MD, Renninger CH.   +7 more
europepmc   +1 more source

Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63‐specific ubiquitination

British Journal of Pharmacology, EarlyView.
▪ Background and Purpose NLRP3 is up‐regulated in inflammatory and autoimmune diseases. The development of NLRP3 inhibitors is challenged by the identification of compounds with distinct mechanisms of action avoiding side effects and toxicity. Triptolide is a natural product with multiple anti‐inflammatory activities, but a narrow therapeutic window ...
Mo‐Yu Ding, Chengqing Ning, Shao‐Ru Chen, Hao‐Ran Yin, Jing Xu, Ying Wang   +5 more
wiley   +1 more source

New insights on femoral head trabecular bone directionality in elderly humans using a micro-CT-based analysis. [PDF]

Sci Rep
Hadad A, Bar-Ziv Y, May H.
europepmc   +1 more source

Phosphodiesterase 3 inhibitors boost bone outgrowth

British Journal of Pharmacology, EarlyView.
Background and Purpose C‐type natriuretic peptide (CNP) stimulates skeletal growth by acting on the growth plates of long bones, and a CNP variant is clinically used for achondroplasia treatment. We previously reported that CNP stimulates the autonomic Ca2+ influx mediated by TRPM7 channels in growth plate chondrocytes to facilitate extracellular ...
Takaaki Kawabe, Atsuhiko Ichimura, Tomoki Yasue, Jianhong Li, Haruki Ishikawa, Ga Eun Kim, Hiroki Nagatomo, Naoto Minamino, Yohei Ueda, Hiromu Ito, Miyuki Nishi, Hiroshi Takeshima   +11 more
wiley   +1 more source

Weight-Bearing Approaches After Neck of Femur Fractures: A Narrative Review of Evidence and Outcomes. [PDF]

Cureus
Patel N, Chaudhari M.
europepmc   +1 more source

New perspectives on body size and shape evolution in dinosaurs

Biological Reviews, EarlyView.
ABSTRACT Diversity in the body shapes and sizes of dinosaurs was foundational to their widespread success during the Mesozoic era. The ability to quantify body size and form reliably is therefore critical to the study of dinosaur biology and evolution.
Matthew Dempsey, Samuel R. R. Cross, Susannah C. R. Maidment, John R. Hutchinson, Karl T. Bates   +4 more
wiley   +1 more source

Impact of Comorbidities on the Prevalence and Recovery Outcomes in Elderly Patients With Neck of Femur Fractures. [PDF]

Cureus
Khan Z, Swati MAA, Zia A, Imran A, Ashraf, Rumman, Ali A.   +6 more
europepmc   +1 more source

Lifestyle Management in Menopause: A Systematic Review of Women With Premature Ovarian Insufficiency

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Premature ovarian insufficiency (POI), the loss of ovarian function before age 40, increases the risk of cardiovascular disease, low bone mineral density, dementia and psychological distress. Lifestyle interventions reduce chronic disease risk in other populations and, with hormone therapy, may improve health outcomes in POI.
Ladan Yeganeh, Nathalie Vermeulen, Carolyn Ee, Helena Teede, Amanda J. Vincent   +4 more
wiley   +1 more source

Twenty-Four-Year Follow-up of Successful Total Hip Arthroplasty for Recurrent Proximal Femoral Aneurysmal Bone Cyst with a Pathologic Fracture Following Extended Curettage and Bone Grafting: A Case Report. [PDF]

J Orthop Case Rep
Pachore JA, Shah VI, Jhunjhunwalla HR, Babu C, Parameswaran A, Eachempati KK.   +5 more
europepmc   +1 more source

Aarskog Syndrome: Deep Phenotyping and Genomic Landscape of a New Cohort Including Adult Patients

Clinical Genetics, EarlyView.
This study presents the deep phenotyping data of 14 new Aarskog‐Scott syndrome patients with molecular confirmation. ABSTRACT Aarskog‐Scott syndrome (AAS, MIM#305400) is an X‐linked disorder characterized by recognizable facial features, short stature, and genitourinary and skeletal malformations.
Gozde Tutku Turgut, Umut Altunoglu, Şahin Avcı, Tuğba Kalaycı, Ayça Dilruba Aslanger, Volkan Karaman, Zehra Oya Uyguner, Hülya Kayserili   +7 more
wiley   +1 more source