Results 301 to 310 of about 744,744 (361)

Predicted foot and mouth disease virus and African swine fever virus inactivation within carcases undergoing field decomposition in three Australian climate zones

open access: yesAustralian Veterinary Journal, EarlyView.
Australia's large populations of feral and extensively farmed livestock pose challenges to implementing response plans in the event of an Emergency Animal Disease outbreak. This study aimed to determine if a “Destroy and Let Lie” approach to carcase disposal (leaving carcases in situ to decompose naturally after field euthanasia) would reliably ...
TS Barnes   +9 more
wiley   +1 more source

Discovery of natural product derivative triptolidiol as a direct NLRP3 inhibitor by reducing K63‐specific ubiquitination

open access: yesBritish Journal of Pharmacology, EarlyView.
▪ Background and Purpose NLRP3 is up‐regulated in inflammatory and autoimmune diseases. The development of NLRP3 inhibitors is challenged by the identification of compounds with distinct mechanisms of action avoiding side effects and toxicity. Triptolide is a natural product with multiple anti‐inflammatory activities, but a narrow therapeutic window ...
Mo‐Yu Ding   +5 more
wiley   +1 more source

Surgical treatment of monostotic fibrous dysplasia of the proximal femur in children and adolescents: Observational European Paediatric Orthopaedic Society multicenter study. [PDF]

open access: yesJ Child Orthop
van Geloven TP   +18 more
europepmc   +1 more source

Phosphodiesterase 3 inhibitors boost bone outgrowth

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose C‐type natriuretic peptide (CNP) stimulates skeletal growth by acting on the growth plates of long bones, and a CNP variant is clinically used for achondroplasia treatment. We previously reported that CNP stimulates the autonomic Ca2+ influx mediated by TRPM7 channels in growth plate chondrocytes to facilitate extracellular ...
Takaaki Kawabe   +11 more
wiley   +1 more source

New perspectives on body size and shape evolution in dinosaurs

open access: yesBiological Reviews, EarlyView.
ABSTRACT Diversity in the body shapes and sizes of dinosaurs was foundational to their widespread success during the Mesozoic era. The ability to quantify body size and form reliably is therefore critical to the study of dinosaur biology and evolution.
Matthew Dempsey   +4 more
wiley   +1 more source

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