Results 71 to 80 of about 51,881 (265)

Mechanical Strain‐Programmed SDC1+ Sheath Fibroblasts Trigger CXCR4hi Neutrophil‐Mediated Enthesitis in Ankylosing Spondylitis

open access: yesAdvanced Science, EarlyView.
In ankylosing spondylitis (AS), mechanical strain‐programmed SDC1+ sheath fibroblasts secrete CXCL5 to recruit neutrophils and promote the activation of CXCR4hi neutrophils, thereby exacerbating enthesitis by promoting neutrophil extracellular traps (NETs) formation. SOX5 controls the generation of SDC1+ sheath fibroblasts via super‐enhancers.
Jiajie Lin   +13 more
wiley   +1 more source

Increased associated risk of postoperative periprosthetic femur fracture with cementless versus cemented hemiarthroplasty: a nationwide database study of 24,419 femoral neck fractures

open access: yesOTA International
. Objective:. We evaluated the associated risk of postoperative periprosthetic femur fracture after hemiarthroplasty for the treatment of femoral neck fracture based on stem fixation, cementless compared with cemented. Design:.
Frank Rodgers, MD   +4 more
doaj   +1 more source

Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle

open access: yesAdvanced Science, EarlyView.
Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner   +14 more
wiley   +1 more source

Bioinspired Engineering of Streamlined Skeletal Interoception: Neural Bioprinted Piezoelectric Scaffolds for Neuro‐Vascularized Bone Regeneration

open access: yesAdvanced Science, EarlyView.
This study develops neural bioprinted piezoelectric scaffolds which construct local “sensor‐effector” circuit, inspired by the skeletal interoception system. Upon US stimulation sensing and mechanoelectrical coupling by PLLA nanofibers, the incorporated DRG neurons effect through Ca2+ influx‐induced enhanced secretion and expression of CGRP.
Yingze Su   +18 more
wiley   +1 more source

Roadmap on Artificial Intelligence‐Augmented Additive Manufacturing

open access: yesAdvanced Intelligent Systems, EarlyView.
This Roadmap outlines the transformative role of artificial intelligence‐augmented additive manufacturing, highlighting advances in design, monitoring, and product development. By integrating tools such as generative design, computer vision, digital twins, and closed‐loop control, it presents pathways toward smart, scalable, and autonomous additive ...
Ali Zolfagharian   +37 more
wiley   +1 more source

Neck of Femur Fracture among Senior Citizen Managed with Hemiarthroplasty in a Tertiary Care Center in Nepal: An Observational Study

open access: yesJournal of Nepal Medical Association
Introduction: Hemiarthroplasty is recognized as a prominent therapeutic option for neck of femur fracture without preexisting acetabular  pathology; however, there are controversies in the scientific literature regarding this.
Bijay Poudel   +8 more
doaj   +1 more source

Homozygous Achondroplasia With Long‐Term Survival: Growth Patterns, Medical Interventions, and Practice Implications

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Homozygous achondroplasia is widely considered perinatal lethal by the medical community. In this case series, we report two children from a single family with longer‐term survival. One child lived for 17 months and the other was 60 months at the time of publication.
Hannah Singerline   +3 more
wiley   +1 more source

REGIONAL VARIATION OF MORPHOMETRIC MEASUREMENTS OF PROXIMAL END OF FEMUR IN COASTAL ANDHRA PRADESH AND ITS CLINICAL IMPLICATION TO IMPROVE SURGICAL OUTCOME

open access: yesNational Journal of Medical Research, 2017
Introduction: The neck of femur is an important modification in human being. The neck-shaft angle and different parameters of neck are clinically important to diagnose pathological conditions of the hip joint and also helpful in the treatment and follow-
Tapati Roy   +3 more
doaj  

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