Results 71 to 80 of about 443,081 (251)

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Interleukin‐1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis

Advanced Science, EarlyView.
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum, Shenja Buchholz, Hanna Schifter, Sabine Ameling, Leif Steil, Ben Lewin Becker, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Lukas Zierke, Frank Ulrich Weiss, Juliane Glaubitz, Matthias Sendler   +13 more
wiley   +1 more source

FEMORAL NECK ANTEVERSION: IS THE SIDE WISE DIFFERENCE SIGNIFICANT?

Gomal Journal of Medical Sciences, 2014
Background: Femoral anteversion is one of the most important parameter of femur anatomy and geometry having important clinical implications. The objective of this study was to determine the side wise variation in femoral neck anteversion angle in adult
Wali Ullah Khan, Malik Javaid Iqbal, Muhammad Marwat, Maqbool Ilahi   +3 more
doaj  

Atraumatic femoral neck fracture secondary to prolonged lactation induced osteomalacia

Medical Journal of Dr. D.Y. Patil University, 2013
Presenting a case of atraumatic fracture neck femur secondary to 2 years of prolonged lactation. A 26-year-old lactating mother presented with pain in left hip from last 12 months. She was apparently alright before and during pregnancy.
Dhammapal Sahebrao Bhamare, Praful Herode, Abhijeet Shroff, Bharati Deokar, Samar K Biswas   +4 more
doaj   +1 more source

The morphology of the knee joint in Homo sapiens : a morphometric study of form variation in the distal femur and proximal tibia. [PDF]

, 2005
This thesis explores form variation in the knee joint of thirteen geographically and economically distinct populations of modern Homo Sapiens from different ancestral backgrounds.
Stevens, Sally Diane
core  

Desmoid tumors of the head and neck: A therapeutic challenge

, 2014
Item does not contain fulltextDesmoid tumor, or aggressive fibromatosis, is a rare, histologically benign, fibroblastic lesion that infrequently presents in the head and neck.
Eelco de Bree, Shaha, Ashok R., Zoras, O., Bree, R. de, Hunt, Jennifer L., Ferlito, Alfio, Remco de Bree, Takes, Robert P., Alessandra Rinaldo, Mendenhall, William M., Michael L. Hinni, Hunt, J.L., Rinaldo, Alessandra, Jennifer L. Hunt, Juan P. Rodrigo, Mendenhall, W.M., Rodrigo Tapia, Juan Pablo, Bree, Remco de, Takes, R.P., Ferlito, A., Suárez Nieto, Carlos, Hinni, Michael L., Alfio Ferlito, de Bree, E., Zoras, Odysseas, Robert P. Takes, Carlos Suárez, Odysseas Zoras, Bree, Eelco de, de Bree, R., Ashok R. Shaha, Suarez, C., Shaha, A.R., William M. Mendenhall, Bree, E. de, Hinni, M.L., Rodrigo, J.P., Rinaldo, A.   +37 more
core   +1 more source

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source

Printing‐Assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling

Advanced Science, EarlyView.
Extrusion‐based 3D printing of silicones and discrete electronic components are combined to create cortical implants for rodents that integrate thermal neuromodulation and electrical recording. Linked to an autonomous auxiliary driver unit, the system enables rapid, stable and localized hypothermia alongside ECoG recording.
Spencer Ryan Moore, Naomi King, Aruã Clayton Da Silva, Clare Howarth, Jason Berwick, Thomas E. Paterson, Ivan R. Minev   +6 more
wiley   +1 more source

Neck pain and disability: A cross-sectional survey of the demographic and clinical characteristics of neck pain seen in a rheumatology clinic [PDF]

, 2004
This hospital-based cross-sectional cohort study examines the clinical and demographic features of neck pain, disability (using the Northwick Park neck pain questionnaire) and relationships to handicap in employment.
C.A. Frank, Frank, AO, Frank, CA, L.H. De Souza, A.O. Frank, De Souza, LH   +5 more
core   +1 more source