Results 111 to 120 of about 580 (130)

Fenebrutinib shows rapid reduction of new Gd+ T1 lesions

Medicom Conference Report MSMilan 2023, 2023
exaly   +2 more sources

A Two-part, Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Fenebrutinib (Part A) and the Effect of Fenebrutinib on the QT/QTc Interval in Healthy Participants (Part B) (P10-6.011)

Neurology
Jiajie Yu
exaly   +2 more sources

Safety and efficacy of fenebrutinib in relapsing multiple sclerosis (FENopta): a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial and open-label extension study

Lancet Neurology, The
The prospect for Bruton's tyrosine kinase (BTK) inhibition to meaningfully affect relapsing multiple sclerosis has recently been questioned due to inconsistent findings in the magnitude and sustainability of the effect of BTK inhibitors on disease activity.
Radek Ampapa, Svetlana Miletic Drakulić, Sanja Grgic   +2 more
exaly   +4 more sources

The Safety Profile of Fenebrutinib in Patients with Multiple Sclerosis Is Consistent with Those in Previously Studied Autoimmune Indications (P9-6.012)

Neurology
Maresa Caunt
exaly   +2 more sources

Impact of Fenebrutinib Treatment on MRI Outcomes and Cerebrospinal Fluid Penetrance in Multiple Sclerosis: Results from the Phase II FENopta Study (S31.004)

Neurology
Michal Dufek, Julie Napieralski
exaly   +2 more sources

MS activity remains low on long-term fenebrutinib

Medicom Conference Report ACTRIMS 2025
exaly   +2 more sources

167 Fenebrutinib maintains low disease activity in relapsing multiple sclerosis: results from the FENopta open-label extension

Journal of Neurology, Neurosurgery and Psychiatry
Gran Bruno, Bar-Or Amit, Oh Jiwon, Dufek Michal, Budincevic Hrvoje, Habek Mario, Caunt Maresa, Thomas Piia, Sierzega Malgorzata, Clayton et al. David   +9 more
exaly   +2 more sources

Disrupting neuropathy-associated HSPB1 S135F/α-tubulin interaction by fenebrutinib restores autophagic clearance of misfolded proteins in stressed cells

Charcot-Marie-Tooth disease (CMT) is the most common inherited peripheral neuropathy. The small heat shock protein HSPB1 is a ubiquitously expressed molecular chaperone and its S135F mutation has been linked to both axonal CMT and distal hereditary motor neuropathy.
Caiyan Wei, Yuemeng Xiang, Yongzhen Yu, Qianqian Cai, Haidong Xu, Hong Ni, Qiang Fu, Juan Xing, Xianchao Pan   +8 more
openaire   +1 more source

Investigation of Fenebrutinib Metabolism and Bioactivation Using MS3 Methodology in Ion Trap LC/MS

Molecules, 2023
Adnan Kadı, Haya aljohar, Mohamed W Attwa   +2 more
exaly  

Fenebrutinib Versus Placebo or Adalimumab in Rheumatoid Arthritis: A Randomized, Double-Blind, Phase II Trial

Arthritis and Rheumatology, 2020
Mark C Genovese, Liudmyla Khimion, Dmytro Fedkov   +2 more
exaly