Results 81 to 90 of about 17,325,407 (260)

Functional Roles of Adenosine A2B and A3 Receptor Subtypes in the Bladder of Male Rats With A2B Receptor Deletion or Bladder Outlet Obstruction

Neurourology and Urodynamics, EarlyView.
ABSTRACT Purpose To investigate the adenosine receptor (AR) mechanism underlying bladder outlet obstruction (BOO)‐related bladder dysfunction, we examined the expression level of AR subtypes in bladder tissues, and the effects of AR subtypes A2B & A3 modulation on bladder activity using male BOO rats, and Dahl rats with A2B receptor deletion. Materials
Masahiro Kurobe, Ei‐ichiro Takaoka, Kanako Matsuoka, Shingo Kimura, Anne M. Robertson, Edwin K. Jackson, Lori A. Birder, Minoru Miyazato, Naoki Yoshimura   +8 more
wiley   +1 more source

Mesenchymal stem cells as cellular factories for targeted P2X7 blockade after traumatic brain injury

Neuroprotection, EarlyView.
This manuscript presents a novel therapeutic strategy using mesenchymal stem cells (MSCs) engineered as living drug factories to deliver a P2X7‐blocking nanobody for treatment of ischemic stroke. By combining targeted cellular delivery with sustained local immunomodulation, the approach aims to overcome key limitations of systemic biologic ...
Lucia Fadon‐Padilla, Chengyan Chu, Lorissa McDougall, Yajie Liang, Chinmoy Sarkar, Marta Lipinski, Tim Magnus, Miroslaw Janowski, Piotr Walczak   +8 more
wiley   +1 more source

Seven‐Year Delayed Diagnosis of a Giant Suprasellar Arachnoid Cyst Presenting With Progressive Gait Disturbance: Successful Endoscopic Ventriculocystocisternostomy—A Case Report [PDF]

Clin Case Rep
ABSTRACT Suprasellar arachnoid cysts are uncommon pediatric lesions that may cause obstructive hydrocephalus and optic pathway compromise, often with insidious clinical progression. We report an 11‐year‐old boy who presented with a 7‐year history of progressive gait disturbance and imbalance.
Ibrahem Z, Almjersah A, Mouselli A, Saleh I, Alromhain B.   +4 more
europepmc   +2 more sources

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

Responsive Materials, EarlyView.
This review presents the structure and transport routes of the blood‐brain barrier, summarizes the ischemic stroke pathophysiological cascade, and discusses the BBB‐crossing mechanisms and multitarget therapeutic effects of carbon dots, demonstrating their promising theranostic potential for ischemic stroke.
Yanhan Huang, Xuan Hou, Haiping Zhao, Qi Kong, Xiayan Wang, Xiaokun Geng, Zaicheng Sun   +6 more
wiley   +1 more source

Interference Of Frame And Glass Systems And Their Impact On Thermal Performance Of Fenestration Systems

Procedia Engineering, 2011
AbstractThe paper focuses on the analysis of thermo technical interaction of frame and glass systems in a selected type of window construction, which is currently an important factor of building design that concerns cold and moderate climates. The analysis was based on the laboratory experiment in a climate chamber with a hot box for particular ...
Bagona, Miloslav, Lopusniak, Martin
openaire   +1 more source

Gut microbiota dysbiosis in the inflammatory pathogenesis of diabetic retinopathy

VIEW, EarlyView.
This graphical abstract illustrates how gut dysbiosis drives diabetic retinopathy through the gut‐retina axis, a process unfolding in three interconnected stages. First, in the gut, a decrease in beneficial bacteria and an increase in pro‐inflammatory taxa compromise the intestinal barrier, causing a “leaky gut” that allows LPS to translocate into the ...
Junyan Hu, Jingxiang Zhong
wiley   +1 more source

Incidence and factors influencing the spontaneous closure of Fontan fenestration

, 2018
Introduction The Fontan operation is the final stage of single ventricle palliation in patients with complex congenital heart disease. Fenestration in the Fontan conduit, providing an atrial level right to left shunt, has been shown to reduce early ...
Chakraborty, Abhishek, Sandhu, Satinder, Raja, Kishore R, Rosenkranz, Eliot R, Swaminathan, Sethuraman, Garg, Ashish, Gorla, Sudheer R, Jhingoeri, Nataley K   +7 more
core   +1 more source

Risk for laparoscopic fenestration of liver cysts

, 2003
Background: Laparoscopic fenestration is considered the best treatment for symptomatic simple liver cysts. Conversely, the laparoscopic approach for the management of hydatid simple liver cysts is not widely accepted because of the risk for severe ...
D'Acapito, Fabrizio, Giovannini, Ivo, Giuliante, Felice, Vellone, Maria, Nuzzo, Gennaro   +4 more
core   +2 more sources

Decoding Vitruvius — Modulation of a Sequenced Nominal Value of a Fixed Module by Ad Triangulum Geometry

Peristil
The sequencing of circles congruent with a (divided) column diameter – a visualization of the Vitruvian concept of a fixed module – is expanded by the inclusion, in the same scale, of geometric figures intrinsic to the ad triangulum method.
Duško Čikara
doaj   +1 more source

Evaluation for the safety and effectiveness of the in situ fenestration system in TEVAR for aortic arch pathologies: protocol for a prospective, multicentre and single-arm study. [PDF]

BMJ Open, 2021
Sun X, Kan Y, Huang L, Dong Z, Guo D, Si Y, Fu W.   +6 more
europepmc   +1 more source