Results 81 to 90 of about 9,926 (208)

Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic (CKLM) syndrome.
Virginia Anagnostopoulou, Christoforos K. Travlos, Lucas Lage Marinho, Thomas A. Mavrakanas, João Pedro Ferreira, Abhinav Sharma   +5 more
wiley   +1 more source

A new era beckons in asthma: enhanced models of care, disease remission, artificial intelligence and consumer participation

Internal Medicine Journal, EarlyView.
Abstract The landscape of asthma management is undergoing significant transformation. This change is driven by several factors: deeper understanding of asthma pathophysiology, appreciation of the long‐term harm of oral corticosteroids, biological treatments that dramatically improve patient outcomes with asthma remission becoming a realistic goal, and ...
John Politis, Kerry Hancock, Jo A Douglass, Paul Leong, Philip Bardin   +4 more
wiley   +1 more source

Agonist‐specific conformational dynamics at the β2‐adrenoceptor dictate allosteric modulation of Gαs signalling and bronchodilation

British Journal of Pharmacology, Volume 183, Issue 17, Page 5315-5335, September 2026.
Abstract Background and Purpose β2‐adrenoceptor (β2AR) agonists are the cornerstone of asthma therapy and promote bronchodilation through Gαs signalling in airway smooth muscle (ASM), but their efficacy is limited by β‐arrestin‐mediated β2AR desensitization.
Sushrut D. Shah, Joshua Richard, Suvankar Ghosh, Jillian Jerwick, Joice T. Gavali, Raymond B. Penn, Alexander D. MacKerell Jr, Deepak A. Deshpande   +7 more
wiley   +1 more source

The diagnostic value of combined pulmonary function test and exhaled nitric oxide monitoring in cough variant asthma with or without gastroesophageal reflux disease: a retrospective study

BMC Pulmonary Medicine
Introduction This study aimed to investigate the effect of fractional exhaled nitric oxide (FeNO), a marker of airway inflammation, together with small airway function tests in diagnosing cough variant asthma (CVA), particularly in patients with ...
Sen Li, Siyao Xu, Yuan Yang, Zhe Wang, Yaru Hou   +4 more
doaj   +1 more source

Relationship Between Bronchodilator Reversibility and Spirometry Response to Dupilumab in Type 2 High Uncontrolled Severe Asthma

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 253-255, March 2025.
Robert Greig, Kirsten Stewart, Chris RuiWen Kuo, Rory Chan, Brian Lipworth   +4 more
wiley   +1 more source

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

Evaluation of Small Airways Dysfunction With Dupilumab Using Airway Oscillometry in Uncontrolled Severe Asthma

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 264-266, March 2025.
Kirsten E. Stewart, Chris RuiWen Kuo, Rory Chan, Brian J. Lipworth   +3 more
wiley   +1 more source

Improvement of Severe Volume Dependent Airway Closure With Tezepelumab: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Severe asthma may be complicated by airway remodeling, manifesting as higher symptom burden, airflow limitation and reduced treatment response. The effect of biologics on lung function changes remains uncertain. We report a 31‐year‐old man with severe uncontrolled asthma and chronic rhinosinusitis with nasal polyposis, characterized by ...
Philipp Suter, Robert Greig, Rory Chan, Brian J. Lipworth   +3 more
wiley   +1 more source

Very Long‐Term Stability of Tryptase in Frozen Serum Samples

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 276-277, March 2025.
Florent Broussal, Thomas Rouzioux, Dounia Khelifi‐Touhami, Sibylle Bachelier, Brigitte Berthier, Aicha Abbas, Simone Choi, Yannick Chantran   +7 more
wiley   +1 more source

Corticosteroid Exposure in Chronic Rhinosinusitis and Global Airway Disease: Adrenal and Bone Impact

The Laryngoscope, Volume 136, Issue 8, Page 3398-3409, August 2026.
ABSTRACT Objective To investigate cumulative corticosteroid (CC) burden in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), with or without coexisting asthma (global airway disease, GAD), referred for biologic treatment, and to assess the prevalence of CC‐related comorbidities, including secondary adrenal insufficiency, osteopenia and ...
Christiane Haase, Kjell Erik Julius Håkansson, Peter Schwarz, Kasper Aanæs, Jens Tidemandsen, Charlotte Suppli. Ulrik, Bente Appel Esbensen, Vibeke Backer   +7 more
wiley   +1 more source