Results 31 to 40 of about 9,893 (211)
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin and is approved for adolescents and adults with severe asthma. This analysis assessed pharmacokinetics (PK), pharmacodynamics and safety of tezepelumab up to 85 days postdose in adolescents and children.
Anna Lundahl +14 more
wiley +1 more source
Acta Scientiarum: Animal Sciences, 2007 O trabalho teve como objetivo avaliar o tratamento do feno de grama-estrela(Cynodon nlemfuensis Vanderyst) com uréia sobre a digestibilidade da dieta em ovinos. Osfenos foram tratados com uréia na proporção de 2, 4 e 6% com base na MS.
Moisés Calixto Júnior +3 more
doaj +1 more source
Therapeutic Advances in Respiratory Disease, 2023 Background: The diagnosis of cough-variant asthma (CVA) is based on bronchial provocation test, which is challenging to be conducted. Most CVA patients have type 2 airway inflammation and small airway dysfunction.
Haodong Bai +6 more
doaj +1 more source
The Role of Iron‐Hyponitrite Intermediates in Biology and Insights From Synthetic Model Complexes
Chemistry – A European Journal, EarlyView.Despite the difference in active site architecture, NO reduction by different NOR enzymes is expected to be linked by a common intermediate: hyponitrite (N2O22−). However, experimentally, very little is known about the coordination chemistry of iron with hyponitrite and the expected Fe‐hyponitrite intermediates.
Michael O. Lengel, Nicolai Lehnert
wiley +1 more source
The value of FeNO measurement in asthma management: the motion against FeNO to help manage childhood asthma – reality bites [PDF]
Paediatric Respiratory Reviews, 2008 Since exhaled nitric oxide (FeNO) was first demonstrated to be raised in asthmatic patients in the early 1990s, there has been a strong interest in its potential role in the diagnosis and management of asthma. This culminated in 2003 when the US Food and Drug Administration cleared the NIOX nitric oxide analyser for clinical application in patients ...
Peter J, Franklin, Stephen M, Stick
openaire +2 more sources
ClinicoEconomics and Outcomes Research, 2021 Josep Darbà,1 Meritxell Ascanio,2 Jörgen Syk,3– 5 Kjell Alving4 1Department of Economics, Universitat de Barcelona, Barcelona, Spain; 2BCN Health Economics & Outcomes Research, S.L., Barcelona, Spain; 3Department of Neurobiology ...
Darbà J, Ascanio M, Syk J, Alving K
doaj
Environmental Toxicology, EarlyView.ABSTRACT Sargassum inundation of Caribbean and American shorelines is a growing environmental hazard. Hydrogen sulfide (H2S) and ammonia (NH3) produced by decomposing Sargassum could be involved in airway obstruction and bronchial inflammation. The study was undertaken to evaluate the effects of exposure to H2S and NH3 gases emitted during Sargassum ...
Rishika Banydeen +9 more
wiley +1 more source
Canadian Respiratory Journal, 2020 Background. FeNO has been used as a marker for Th2-mediated airway inflammation in asthma. There is evidence which recommends the use of this biomarker in asthma management. Little is known about whether the FeNO test alone or in combination with the ACT
Vinh Nguyen Nhu +2 more
doaj +1 more source
Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
Effect of mannitol dry powder challenge on exhaled nitric oxide in children. [PDF]
PLoS ONE, 2013 BackgroundFractional exhaled nitric oxide (FENO), a non-invasive marker of eosinophilic airway inflammation, is increasingly used for diagnostic and therapeutic decisions in adult and paediatric asthma. Standardized guidelines for the measurement of FENO
Juerg Barben +5 more
doaj +1 more source