Results 281 to 290 of about 153,817 (339)

Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Yonika A. Larasati, Camille Rabesahala de Meritens, Miriam Stoeber, Vladimir L. Katanaev, Gonzalo P. Solis   +4 more
wiley   +1 more source

Effects of Fentanyl-Reduced Regimen with Esketamine and Remimazolam on Bronchoscopy in Elderly Patients. [PDF]

Drug Des Devel Ther
Xie A, Zhang X, Han J, Wu D, Ju F, Zhou Y, Zhou R.   +6 more
europepmc   +1 more source

Recent Advances in Metal‐Based Catalysts for Nitrile Hydration to Amides: Mechanistic Aspects

The Chemical Record, Volume 26, Issue 1, January 10, 2026.
Amide vital functional group plays a key role in the composition of amide‐containing compounds, including peptides, proteins, and amino acids. Demand for innovative amide derivatives grows due to their crucial role in drug development. A cost‐effective method uses metal‐catalyzed hydration of nitriles to amides.
Fatima‐Ezzahraa Essebbar, Hicham Ben El Ayouchia, Hafid Anane, Salah‐Eddine Stiriba   +3 more
wiley   +1 more source

The NOD (Naltrexone for Overdose Prevention) study protocol: a pilot randomized controlled trial of intramuscular naltrexone for opioid overdose prevention among people who use stimulants living with or at risk for HIV. [PDF]

Addict Sci Clin Pract
Appa A, Marti XL, Baral S, Shoptaw S, Bazazi AR, Spinelli MA, Glidden D, Gandhi M, Coffin P.   +8 more
europepmc   +1 more source

Roles of peripheral and central µ₁-opioid receptors in the fentanyl-induced cardiorespiratory responses. [PDF]

Am J Physiol Lung Cell Mol Physiol
Zhuang J, Gao X, Chen Z, Shi S, Xu F.
europepmc   +1 more source

Novel dose- and time-dependent toxicity biomarkers of fentanyl/carfentanyl: uncovered by urine-plasma metabolomics for forensics. [PDF]

Curr Res Toxicol
Xie W, Yang S, Wang X, Liu J, Gao W, Shi Y.   +5 more
europepmc   +1 more source

Development and In Vivo evaluation of liposomal fentanyl nanocarriers using thin-film hydration and AI-based characterization for enhanced analgesic efficacy in anesthesia. [PDF]

Sci Rep
Zare-Zardini H, Saberian E, Jenča A, Jenča A, Petrášová A, Jenčová J, Jarrahzadeh MH.   +6 more
europepmc   +1 more source

How much is too much? A medication use evaluation of VA ICU sedation practice during the COVID-19 pandemic. [PDF]

PLoS One
Murphy IC, Bryan K, Burk M, Jiang R, Cunningham F, Providence S, Rightnour E, Zavala S, Morneau K, Exline T, Rice S, Schmitt T, Drumright K, Lee J, Davids B, Guilbeault T, Klenosky B, Sutherland AM, Rosen A, Ratliff L, Bukowski K, Pisani MA, Franck A, Wong M, Witcher P, Akgün KM.   +25 more
europepmc   +1 more source

Efficacy of fentanyl combined with bupivacaine and morphine for spinal anesthesia during cesarean section: A double-blind randomized controlled trial. [PDF]

J Int Med Res
Li G, Zeng F, Qi X, Tan X, Wang H, Huang X, Li Y, Xia Y.   +7 more
europepmc   +1 more source

Proactive Bias Mitigation When Using Online Survey Panels for Self-Reported Use of Illicitly Manufactured Fentanyl in the General Adult Population.

JAMA Health Forum
Black JC, Rockhill KM, Schow N, Monte AA.   +3 more
europepmc   +1 more source