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Detection of Fentanyl and Fentanyl Analogs
Clinics in Laboratory MedicineIllicitly manufactured fentanyl and fentanyl analogs have led to a drastic increase in opioid related overdose deaths. Sensitive detection of fentanyl exposure requires specific assays that target fentanyl and its major metabolite norfentanyl. Fentanyl immunoassays have varying sensitivity to detect fentanyl analogs but many of the more prevalent ...
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Fentanyl and morphine discrimination in rats continuously infused with fentanyl
Behavioural Pharmacology, 1989Rats were trained to detect the stimulus properties of fentanyl, 0.04mg/kg. Tested acutely, fentanyl generalized to, and morphine substituted for, the fentanyl training stimulus, although morphine was approximately 100-fold less potent than fentanyl in producing this stimulus.
A. Herz +2 more
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Ionic Liquid-Modified Disposable Electrochemical Sensor Strip for Analysis of Fentanyl.
Analytical Chemistry, 2019The increasing prevalence of fentanyl and its analogues as contaminating materials in illicit drug products presents a major hazard to first responder and law enforcement communities.
S. Goodchild +9 more
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Drug and Alcohol Review, 2019
INTRODUCTION AND AIMS Drug checking is a harm reduction intervention increasingly used in the context of the opioid overdose epidemic. The aim of the study was to determine the limit of detection for fentanyl of two point-of-care drug checking ...
Karen McCrae +6 more
semanticscholar +1 more source
INTRODUCTION AND AIMS Drug checking is a harm reduction intervention increasingly used in the context of the opioid overdose epidemic. The aim of the study was to determine the limit of detection for fentanyl of two point-of-care drug checking ...
Karen McCrae +6 more
semanticscholar +1 more source
Is Fentanyl an Anesthetic in the Dog?
Anesthesia & Analgesia, 1987The authors used the absence of vocalization and movement during application of a hemostat clamped to the first ratchet at the base of the tail as an indication of anesthesia for evaluation of the anesthetic properties of fentanyl in the dog. Eighty-six unpremedicated, unrestrained, untrained mongrel dogs were given one of eight doses of fentanyl ...
L Reinersman +4 more
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Clinical Pharmacology & Therapeutics, 1968
Sublimaze (fentanyl) is a piperidine derivative with the following chemical name: N‐(1‐phenethyl‐4‐piperidyl) propionanilide. It is a potent narcotic analgesic with a rapid onset and short duration of activity.
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Sublimaze (fentanyl) is a piperidine derivative with the following chemical name: N‐(1‐phenethyl‐4‐piperidyl) propionanilide. It is a potent narcotic analgesic with a rapid onset and short duration of activity.
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The Journal of Pharmacology and Experimental Therapeutics, 1975
Immunization of rabbits with carboxyfentanyl-bovine gamma-globulin conjugate induced antibodies of high titers capable of binding with fentanyl. The antibodies exhibited high average association constants (approximately 1 times 10-7 liter/mol) and were highly specific to fentanyl since no cross-reactivity was observed for a variety of test compounds ...
G L, Henderson +4 more
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Immunization of rabbits with carboxyfentanyl-bovine gamma-globulin conjugate induced antibodies of high titers capable of binding with fentanyl. The antibodies exhibited high average association constants (approximately 1 times 10-7 liter/mol) and were highly specific to fentanyl since no cross-reactivity was observed for a variety of test compounds ...
G L, Henderson +4 more
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1991
The fundamental pharmacokinetic properties of any drug are the rate and extent of distribution in the body and the rate and route(s) of elimination from the body. These, as a rule, are determined after intravenous administration. As reported in a variety of studies using traditional compartment pharmacokinetic methodology over the past 10 years, the ...
L. E. Mather, G. K. Gourlay
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The fundamental pharmacokinetic properties of any drug are the rate and extent of distribution in the body and the rate and route(s) of elimination from the body. These, as a rule, are determined after intravenous administration. As reported in a variety of studies using traditional compartment pharmacokinetic methodology over the past 10 years, the ...
L. E. Mather, G. K. Gourlay
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Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review
Neuropharmacology, 2017P. Armenian +3 more
semanticscholar +1 more source