Results 191 to 200 of about 292,850 (308)

Protocol for Reconstituting Adaptor‐Mediated Activation of Full‐Length Kinesin‐1

open access: yesCytoskeleton, EarlyView.
ABSTRACT Kinesin‐1 is a member of the kinesin superfamily that plays an essential role in intracellular cargo transport. In the absence of cargo, Kinesin‐1 exhibits low motor activity due to autoinhibition. Multiple studies have demonstrated that adaptor proteins, which link cargos to Kinesin‐1, can activate Kinesin‐1 by releasing the autoinhibition ...
Haruka Masumoto, Kyoko Chiba
wiley   +1 more source

Patient‐ and Clinician‐Related Factors Associated With the Reduction in Opioid Use Among Adults With Chronic Non‐Cancer Pain: A Systematic Review

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Despite known risks, opioids are widely used for chronic non‐cancer pain (CNCP). Clinical guidelines now recommend deprescribing, but factors predicting success are poorly understood. This systematic review aimed to identify clinician and patient factors associated with attaining successful opioid dose reduction or discontinuation in adults with CNCP ...
Alessandra C. Marcelo   +8 more
wiley   +1 more source

Random finite element analysis on ground subsidence caused by tunnel excavation in karst regions with spatial variable soil

open access: yesDeep Underground Science and Engineering, EarlyView.
This study investigates ground subsidence during tunnel excavation in karst areas, highlighting the combined effects of karst cave proximity, cave size, and soil spatial variability. Findings suggest that shorter cave distances and larger cave sizes increase subsidence variability, and a modified Peck formula is proposed for more accurate subsidence ...
Zhenghong Su   +4 more
wiley   +1 more source

Caving‐enhanced geothermal system overwhelms fracturing‐ and pipe‐enhanced geothermal system in heat extraction

open access: yesDeep Underground Science and Engineering, EarlyView.
Our study reveals that caving‐enhanced geothermal systems (C‐EGS) with adequately fractured reservoirs achieve optimal heat extraction by minimizing preferential flow paths, while conventional fracturing (F‐EGS) and pipe‐based (P‐EGS) systems suffer accelerated thermal drawdown.
Fangchao Kang   +4 more
wiley   +1 more source

Dual‐Functional Sulfonated Nanocellulose for Proton Exchange Membranes With High Proton Conductivity at Low Humidity

open access: yesENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A scalable dual‐functional strategy yields simultaneously sulfonated and nanosized cellulose for proton exchange membranes with continuous hydrogen‐bond networks. These sustainable membranes exhibit low‐humidity proton conductivity twofold higher than Nafion 212, providing a robust solution for next‐generation fuel cells.
Nan Li   +6 more
wiley   +1 more source

Nanozymes for ferroptosis-based cancer theranostics. [PDF]

open access: yesBioact Mater
Khan RU, Qian L, Min J, Peng H, Wang F.
europepmc   +1 more source

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