Results 281 to 290 of about 109,999 (379)

KRAS/ABHD17C/ALOX15B Axis Promotes Pancreatic Cancer Progression via Ferroptosis Evasion

Advanced Science, EarlyView.
Phosphorylation of ABHD17C induced by KRASmut/ERK signaling facilitates ALOX15B depalmitoylation and degradation via the CUL4/DDB1/DCAF10 complex, thereby enabling KRASmut‐PDAC cell to evade ferroptosis. Methyl protodioscin inhibits KRASmut‐PDAC progression by disrupting the ABHD17C/ALOX15B interaction and inducing ferroptosis, which represents a ...
Man Li, Xuexin Yu, Yuanji Liu, Shuqin Ouyang, Long Wu, Xiaohong Chen, Huiqi Yu, Haoming Chen, Senmao Lian, Ziwen Li, Liyun Gong, Libing Song, Jun Li   +12 more
wiley   +1 more source

Ferroptosis in cancer: revealing the multifaceted functions of mitochondria. [PDF]

Cell Mol Life Sci
Ding X, Cui L, Mi Y, Hu J, Cai Z, Tang Q, Yang L, Yang Z, Wang Q, Li H, Hou B, Liu Q, Zou Z, Chen Y.   +13 more
europepmc   +1 more source

<p>Low-Concentration PTX And RSL3 Inhibits Tumor Cell Growth Synergistically By Inducing Ferroptosis In Mutant p53 Hypopharyngeal Squamous Carcinoma</p>

, 2019
Jing Ye, Xiaohua Jiang, Zhihuai Dong, Sunhong Hu, Mang Xiao   +4 more
openalex   +2 more sources

Metal‐Ligand Complexes as Multifunctional Platforms for Photo‐Activated Cancer Therapy

Advanced Science, EarlyView.
Metal‐ligand complexes serve as multifunctional platforms for photo‐activated cancer therapy, facilitating photothermal and photodynamic effects through light absorption and reactive oxygen species generation. This review categorizes these complexes by ligand and metal types, examines their roles in combined therapeutic approaches, and explores ...
Jeonga Kim, Saehan Choi, Yoonsung Nam
wiley   +1 more source

DHODH-mediated mitochondrial redox homeostasis: a novel ferroptosis regulator and promising therapeutic target. [PDF]

Redox Biol
Cao J, Chen X, Chen L, Lu Y, Wu Y, Deng A, Pan F, Huang H, Liu Y, Li Y, Tong X, Du J.   +11 more
europepmc   +1 more source

Neuroprotective effects of Brazilian green propolis on oxytosis/ferroptosis in mouse hippocampal HT22 cells

, 2019
Madoka Takashima, Kenji Ichihara, Yoko Hirata   +2 more
openalex   +2 more sources

Ferroptosis mediated DSS-induced ulcerative colitis associated with Nrf2/HO-1 signaling pathway

, 2020
Yeru Chen, Piao Zhang, Wenru Chen, Gang Chen   +3 more
openalex   +1 more source

A Tailored Artificial Biocatalyst for Bacterial Endophthalmitis Therapy via Enhanced Ferroptosis‐Like Death

Advanced Science, EarlyView.
A tailored bio‐targeted catalytic strategy based on a bacteria‐specific artificial biocatalyst (MoS2/Fe@mercaptophenylboronic acid@hyaluronic acid, MFBH) is proposed for treating bacterial endophthalmitis. This strategy exhibits high‐efficiency peptidoglycan‐targeted bactericidal efficacy in vivo following a single intravitreal injection of an ...
Caixia Sun, Yingying Jiang, Shibo Zhang, Zhipeng Ding, Lijun Pu, Xinmei Liu, Jun Yang, Xiangkai Zhuge, Jianjun Dai, Yanmin Ju   +9 more
wiley   +1 more source

Ferroptosis in central nervous system injuries: molecular mechanisms, diagnostic approaches, and therapeutic strategies. [PDF]

Front Cell Neurosci
Huang Q, Zhang H, Chen S, Wang Y, Zhou J.   +4 more
europepmc   +1 more source

Gut Parabacteroides distasonis‐derived Indole‐3‐Acetic Acid Promotes Phospholipid Remodeling and Enhances Ferroptosis Sensitivity via the AhR‐FASN Axis in Bladder Cancer

Advanced Science, EarlyView.
Indole‐3‐acetic acid (3‐IAA) derived from gut P. distasonis binds to AhR in bladder cancer cells and downregulates FASN transcription, thereby increasing sensitivity to ferroptosis and suppressing the development of bladder tumors. Specifically, 3‐IAA treatment leads to an increase in the proportion of PC/PE‐PUFAs and a decrease in the proportions of ...
Weijia Li, Wentai Shangguan, Wenxue Huang, Jie Zhao, Yuexuan Zhu, Ming Xie, Yao Yu, Qishen Yang, Jun Zheng, Lin Yang, Qi Sun, Leqian Li, Xinhang Shi, Yongyuan Xiao, Hai Huang, Bisheng Cheng, Peng Wu   +16 more
wiley   +1 more source