Results 151 to 160 of about 101,597 (287)

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

Oat protein nanofibril-iron hybrids offer a stable, high-absorption iron delivery platform for iron fortification. [PDF]

Nat Food
Zhou J, Gowachirapant S, Zeder C, Wieczorek A, Guth JN, Kutzli I, Siol S, von Meyenn F, Zimmermann MB, Mezzenga R.   +9 more
europepmc   +1 more source

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, EarlyView.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source

Redox properties of quercetin iron Ii complex with enhanced antioxidant and antiviral activities. [PDF]

Sci Rep
Hameed SEA, El-Maaty WMA, Gomaa EA, Awad FS.   +3 more
europepmc   +1 more source

Universal Solvent Escape Strategies for Efficient Curing of Hydrogen‐Bond‐Rich 3D Printing Inks

Advanced Science, EarlyView.
This study developed a new 3D printing method for hydrogen‐bonded polymers by combining solvent replacement, nanoparticles, and optimized printing paths. This allows fast, precise scaffold fabrication. The scaffolds can be easily customized and release therapeutic agents slowly through protonation, enabling personalized bone, blood vessel, and nerve ...
Jie Chen, Qing Zhao, Wentao Fu, Weixian Chen, Xiaoqian Zhang, Gaiying Ye, Qinglei Meng, Liyuan Shao, Qian Ma, Lin Zhao, Ying Zhao, Weihua Guo   +11 more
wiley   +1 more source

Eco-innovative dyeing of cotton with upcycled pineapple peel waste-derived natural dye. [PDF]

R Soc Open Sci
Pramod K, Perera G, Wijesundara N, De Silva N.   +3 more
europepmc   +1 more source

Thermo‐Responsive Self‐Recoverable Porous Sensors with Writable Electrodes: Advancing Wearable Motion Detection

Advanced Science, EarlyView.
A self‐recoverable flexible porous sensor with diverse designability of electrodes is developed through writable vapor phase polymerization using shape memory polymers (SMPs) as the fundamental materials. The sensors enable long‐term comprehensive human motion detection.
Ying Gao, Xingyi Dai, Yuanyuan Zhang, Guohao Fang, Gui Li, Yu Zheng, Long‐Biao Huang, Biqin Dong   +7 more
wiley   +1 more source

The Effects of Biofortified Cowpeas on Iron, Glucose, and Lipid Metabolism in Rats Fed a High-Fat/High-Sugar Diet. [PDF]

Mol Nutr Food Res
Gaspar APR, Sant' Ana CT, Grancieri M, Cruz APCM, Viana LS, Fornazier EL, Corrêa MDS, Venial HJ, Boeloni JN, Costa NMB.   +9 more
europepmc   +1 more source

Cryo‐EM Structures Reveal the Molecular Basis of Asymmetric Allosteric Activation by MMOB in the Hydroxylase of Soluble Methane Monooxygenase

Advanced Science, EarlyView.
Cryo‐EM analysis reveals an asymmetric MMOH–MMOB complex with distinct protomers, where MMOB binding triggers structural rearrangements from the surface to the active site. This conformational asymmetry shortens the Fe···Fe distance to 2.7 Å in one protomer, forming a geometry suitable for O2 activation and supporting a sequential catalytic mechanism ...
Yunha Hwang, Bumhan Ryu, Soyeon Park, Dong‐Heon Lee, Hyo Jin Hong, Jeong‐Geol Na, Chul Gyu Song, Hyun Goo Kang, Edwin Pozharski, Seung Jae Lee   +9 more
wiley   +1 more source

The ethyl acetate extract from Trichoderma viride fermentation acts by downregulating the leukocyte transendothelial migration signaling pathway to induce ferroptosis in triple-negative breast cancer cells. [PDF]

Nat Prod Bioprospect
Kuang Y, Lu BH, Wu JY, Wu SY, Fu HY, Nan QY, Li J, Yang XL.   +7 more
europepmc   +1 more source