Results 111 to 120 of about 704,728 (295)

NamiRNA‐Enhancer Network: The Changing Era Challenge and Chance of miRNA

open access: yesAdvanced Science, EarlyView.
MiRNAs (miRNAs) regulate diverse biological processes across species. Unlike canonical miRNA‐mediated gene repression, Nuclear Activating miRNAs (NamiRNAs) can efficiently upregulate gene expression by targeting enhancers. This review systematically summarizes recent advances in NamiRNA research, elucidates the theory of NamiRNA‐Enhancer‐mediated Gene ...
Lu Chen   +13 more
wiley   +1 more source

ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.

open access: yesMolecules and Cells, 2013
G. Zheng   +27 more
semanticscholar   +1 more source

Viral Systemic Movement Is Enhanced by Alteration of a Structural Phloem Protein by the Insect Vector

open access: yesAdvanced Science, EarlyView.
Aphids release salivary protein GLD into plants, which induces ROS in the phloem. This leads to the intermolecular disulfide bonds formation among SEO proteins, promoting their transition from the dispersed state to the aggregated state. SEO can interact with CMV CP.
Huijuan Guo   +7 more
wiley   +1 more source

Fertility and infertility: Definition and epidemiology.

open access: yesClinical Biochemistry, 2018
Mélodie Vander Borght, C. Wyns
semanticscholar   +1 more source

Nociceptive Nerve‐Derived CGRP Exacerbates Uterine Fibrogenesis in Adenomyosis by Promoting CD140b+ CD146+ Fibroblast Differentiation

open access: yesAdvanced Science, EarlyView.
This study investigates adenomyosis fibrosis in relation to nociceptive nerves. Nociceptive nerve‐secreted CGRP promotes RAMP1hi CD140b+ CD146+ fibroblast differentiation into myofibroblasts through ERK activation, causing severe fibrosis. Rimegepant‐induced CGRP/RAMP1 signaling blockade alleviates fibrosis and restores fertility in a mouse model. This
Zi Ye   +11 more
wiley   +1 more source

Perspectives of Obstetricians and Gynaecologists on the Use of Weight Loss Medications

open access: yesReproductive, Female and Child Health
Objectives To investigate perspectives of Obstetricians and Gynaecologists on the use of glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) for weight loss in women living with obesity and subfertility. Methods Qualified Obstetricians and Gynaecologists
Ciara Nolan   +4 more
doaj   +1 more source

Hepatic KLF9 Deficiency Inhibits Dehydroepiandrosterone (DHEA)‐Induced Polycystic Ovary Syndrome via Liver‐Ovary Axis

open access: yesAdvanced Science, EarlyView.
The study shows that liver is a previously unrecognized extraovarian organ that plays a key role about androgen homeostasis in the development of DHEA‐induced PCOS. DHEA is the most common precursor of active androgen, such as DHT, and KLF9 is required for the conversion of DHEA to DHT and hepatic KLF9 might be a potential therapeutic target for PCOS ...
Jianli Song   +11 more
wiley   +1 more source

Unusual Van der Waals Magnetoresistance in Stacked Ferromagnetic Fe3GeTe2: The Role of Atomically Sharp Interfaces

open access: yesAdvanced Science, EarlyView.
Angular‐dependent magnetoresistance in stacked Fe3GeTe2 reveals high‐order UAMR that defies spin‐current‐based interpretations. Instead, it originates from internal electric fields at atomically sharp interfaces (ASI), in excellent agreement with two‐vector MR theory.
Qian Chen   +9 more
wiley   +1 more source

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