Results 141 to 150 of about 1,482,535 (355)

Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X‐Linked Hypophosphatemic Rickets

open access: yesAdvanced Science, EarlyView.
The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu   +20 more
wiley   +1 more source

Fertility trends by social status [PDF]

open access: yes
This article discusses how fertility relates to social status with the use of a new dataset, several times larger than the ones used so far. The status-fertility relation is investigated over several centuries, across world regions and by the type of ...
Vegard Skirbekk
core  

ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.

open access: yesMolecules and Cells, 2013
G. Zheng   +27 more
semanticscholar   +1 more source

Aging as a Loss of Goal‐Directedness: An Evolutionary Simulation and Analysis Unifying Regeneration with Anatomical Rejuvenation

open access: yesAdvanced Science, EarlyView.
The paper proposes that the root cause of aging is the loss of anatomical goal‐directedness after development. Using evolutionary neural cellular automata simulations, the authors show that after the organism has reached its developmental homeostatic setpoint (the adult morphology), the absence of target state to pursue leads to a drifting anatomical ...
Léo Pio‐Lopez   +2 more
wiley   +1 more source

The Contraceptive Revolution and the Second Demographic Transition: An Economic Model of Sex, Fertility, and Marriage [PDF]

open access: yes
We present a model of household decisions regarding sex, fertility, marriage, and consumption. Households choose marital status based on the expected utility of marriage, and then sex, children, and consumption of other goods to maximize utility subject ...
Catherine Pakaluk, Joseph Burke
core  

Dissemination and adoption of bottom-up agriculture to improve soil fertility in Africa: An interdisciplinary approach [PDF]

open access: yes, 2018
Soil fertility is at stake at a global scale, putting pressure on food security, poverty alleviation and environmental protection, under scenarios of climate change that in most cases aggravate the threat. In sub-Saharan Africa, a combination of depleted
Adamtey, Noah   +4 more
core  

Thermosensory TRPV Heterotetramers Drive Seasonal Polyphenism: Molecular Basis of CcIav/CcNan‐PKCα‐AKH/AKHR Signaling in Pear Psyllid Morph Transition

open access: yesAdvanced Science, EarlyView.
At 2 5 °C, thermal activation initiates: i) CcIav/CcNan heterotetramer assembly → Ca2⁺ influx; ii) CcPKCα phosphorylation → AKH signaling potentiation; iii) CcAKH1 binding to membrane‐localized CcAKHR → energy mobilization (lipid catabolism/glycogenolysis) and vitellogenin transport via follicular patency; iv) Oocyte maturation → summer‐form nymph ...
Jianying Li   +6 more
wiley   +1 more source

The Economic Foundations of Demographic Transition [PDF]

open access: yes
The paper develops a general equilibrium model where population sources, such as fertility and mortality rates, are chosen variables. It is shown that the evolution of population over time depends on income and relative prices of mortality and fertility ...
Rodrigo Cerda
core   +3 more sources

Home - About - Disclaimer - Privacy