Results 131 to 140 of about 182,992 (312)

The Critical Role of Enhanced OXPHOS and Mitochondrial Hyperpolarization in Simulated Microgravity‐Induced Oocyte Maturation Arrest

open access: yesAdvanced Science, EarlyView.
Simulated microgravity induces distinct mitochondrial hyperactivation patterns‐elevated OXPHOS and MMP‐which accelerate meiosis without SAC failure but delays MTOC coalescence, leading to spindle defects and meiotic arrest. Prolonging M‐phase restores MTOC assembly and oocyte maturation.
Lei Ge   +7 more
wiley   +1 more source

EETs Reduction Contributes to Granulosa Cell Senescence and Endometriosis‐Associated Infertility via the PI3K/AKT/mTOR Signaling Pathway

open access: yesAdvanced Science, EarlyView.
1) 14, 15‐EET levels were decreased in ovarian granulosa cells, follicular fluid, peritoneal fluid from endometriosis patients. 2) EETs reduction in endometriosis follicular fluid aggravated granulosa cell senescence. 3) ROS reduced 14, 15‐EET levels by upregulating EPHX2 through a mechanism involving histone methylation modification.
Xiang Lin   +11 more
wiley   +1 more source

Inhibition of AMPKα Pathway by Podocyte GOLM1 Exacerbates Diabetic Nephrology in Mice

open access: yesAdvanced Science, EarlyView.
Podocyte Golgi membrane protein 1 interacts with epidermal growth factor receptor to inhibit peroxisome proliferator activated receptor γ, and then inactivates adenosine monophosphate activated protein kinase α pathway, which facilitates diabetes‐related inflammation, oxidative damage, apoptosis, and renal dysfunction.
Peng Xu   +14 more
wiley   +1 more source

Manipulating Unisexual–Sexual Reproduction Transition to Engineer Genome‐Reconstructed Polyploids

open access: yesAdvanced Science, EarlyView.
This study developed an efficient approach to generate genome‐reconstructed polyploids involving unisexual gynogenetic Carassius gibelio, sexual C. auratus, and sexual C. cuvieri. The selected superior clone inherited gynogenesis ability of C. gibelio and herpesvirus resistance of wild C.
Meng Lu   +9 more
wiley   +1 more source

Genetic Evidence Supporting a Role for Brain Region Volume and Functional Network Alterations in Major Depression

open access: yesAdvanced Science, EarlyView.
Genome‐wide analyses indicate that reduced ventral diencephalon and thalamus volumes, along with decreased functional connectivity within the triple network (DMN/CEN/SN), are uniquely associated with the risk of major depression (MD) onset, compared to other similar severe psychiatric disorders.
Ming‐Min Xu   +7 more
wiley   +1 more source

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