Results 31 to 40 of about 224,190 (313)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Effects of long-term fertilizer practices on rhizosphere soil ammonia oxidizer community structure under the double-cropping rice field

Scientific Reports
Ammonia oxidation plays a vital role in regulating soil nitrogen (N) cycle in agricultural soil, which is significantly influenced by different fertilizer regimes.
Haiming Tang, Li Wen, Lihong Shi, Kaikai Cheng, Geng Sun, Mei Sun, Weiyan Li   +6 more
doaj   +1 more source

Tillage with Crop Residue Returning Management Increases Soil Microbial Biomass Turnover in the Double-Cropping Rice Fields of Southern China

Agronomy
The variety of soil microbial biomass carbon (SMBC), soil microbial biomass nitrogen (SMBN) content, and the flux turnover rate of SMBC and SMBN for 0–10 cm and 10–20 cm layers in a paddy field in southern China with different tillage practices were ...
Haiming Tang, Chao Li, Lihong Shi, Li Wen, Weiyan Li, Kaikai Cheng, Xiaoping Xiao   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Biochar-Based Fertilizer Enhances the Production Capacity and Economic Benefit of Open-Field Eggplant in the Karst Region of Southwest China

Agriculture, 2022
Biochar as an amendment has been widely applied to enhance crop productivity and improve soil quality. However, the effect of biochar-based fertilizer (BF) on the production capacity and economic benefits of open-field eggplant in the karst region ...
Meng Zhang, Yanling Liu, Quanquan Wei, Lingling Liu, Xiaofeng Gu, Jiulan Gou   +5 more
doaj   +1 more source

Fertilization 2: Polyspermic Fertilization [PDF]

, 2017
During fertilization in animals, a haploid egg nucleus fuses with a haploid sperm nucleus to restore the diploid genome. In most animals including mammals, echinoderms, and teleostei, the penetration of only one sperm into an egg is ensured at fertilization because the entry of two or more sperm is prevented by polyspermy block systems in these eggs ...
openaire   +3 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

A Noval Solar Simulator to Explore Envirnoment Impacts On Panel Efficiency

Sukkur IBA Journal of Emerging Technologies
The paper provided a complete hardware design for a solar simulator for versatile environmental conditions. These conditions include shading, humidity, dust, and temperature.
Shaheer Ahmad Zafar, Nasif Raza Jaffri, Toseef Abid, Usama Abrar   +3 more
doaj   +1 more source