Results 21 to 30 of about 150,451 (313)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Farming, fertilizers and the greenhouse effect

, 1995
The atmospheric concentration of the greenhouse gas methane has more than doubled in the past 100 years as a result of increases in methane sources such as paddy cultivation, ruminant husbandry and fossil fuel combustion.
Toby Willison, Willison, T. W., Webster, C. P., Powlson, D. S., Keith Goulding, David Powlson, Goulding, K. W. T., Colin Webster   +7 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Engineering multifunctional rhizosphere probiotics using consortia of Bacillus amyloliquefaciens transposon insertion mutants

eLife, 2023
While bacterial diversity is beneficial for the functioning of rhizosphere microbiomes, multi-species bioinoculants often fail to promote plant growth.
Jingxuan Li, Chunlan Yang, Alexandre Jousset, Keming Yang, Xiaofang Wang, Zhihui Xu, Tianjie Yang, Xinlan Mei, Zengtao Zhong, Yangchun Xu, Qirong Shen, Ville-Petri Friman, Zhong Wei   +12 more
doaj   +1 more source

Development of a chemotactic SynCom bioorganic fertilizer for biocontrol of bacterial wilt in tobacco fields

Applied Microbiology and Biotechnology
Bacterial wilt caused by Ralstonia solanacearum is one of the most severe plant diseases all over the world. Currently, many scientists are using SynCom (synthetic microbial community) to control this disease.
Yanxia Liu, Weiqi Zhang, Li Guo, Han Li, Jingwei Zhu, Xiang Li, Xiaoni Zhang, Xinrun Yang, Yangchun Xu, Qirong Shen, Tianjie Yang, Zhong Wei   +11 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Proximate analysis and aflatoxin contamination in poultry feeds: a comparative study of two feed companies in Jos and Kaduna, Nigeria

Discover Food
This study investigates the proximate composition, aflatoxin contamination, and their implications on the health and wellbeing of broilers and layers, as well as the comparison from two poultry feed manufacturing feed companies (C1 and C2) located in Jos
Anu Adekunle Daramola, Daniel Omeodisemi Omokpariola   +1 more
doaj   +1 more source

Stimuli-Responsive Nanotherapeutics for Treatment and Diagnosis of Stroke

Pharmaceutics, 2023
Stroke is the second most common medical emergency and constitutes a significant cause of global morbidity. The conventional stroke treatment strategies, including thrombolysis, antiplatelet therapy, endovascular thrombectomy, neuroprotection ...
Manisha Choudhary, Sayali Chaudhari, Tanisha Gupta, Dnyaneshwar Kalyane, Bhagwat Sirsat, Umesh Kathar, Pinaki Sengupta, Rakesh K. Tekade   +7 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Bridging the Gap: Biofilm-mediated establishment of Bacillus velezensis on Trichoderma guizhouense mycelia

Biofilm
Bacterial-fungal interactions (BFIs) are important in ecosystem dynamics, especially within the soil rhizosphere. The bacterium Bacillus velezensis SQR9 and the fungus Trichoderma guizhouense NJAU 4742 have gathered considerable attention due to their ...
Jiyu Xie, Xinli Sun, Yanwei Xia, Lili Tao, Taimeng Tan, Nan Zhang, Weibing Xun, Ruifu Zhang, Ákos T. Kovács, Zhihui Xu, Qirong Shen   +10 more
doaj   +1 more source