Results 141 to 150 of about 1,787,060 (299)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

OP13.02: Reproducibility of fetal brain measurements using 3D ultrasound [PDF]

, 2014
M. Molloholli, Sikolia Wanyonyi, V. Donadono, B. Kemp, T. Norris, Fenella Roseman, Kate M. Edwards, R. Napolitano, Aris T. Papageorghiou   +8 more
openalex   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Updated Clinical Guidelines for Diagnosing Fetal Alcohol Spectrum Disorders

Pediatrics, 2016
H. Hoyme, Wendy Kalberg, Led Ma, A. Elliott, Jason Blankenship, David Buckley, A. Marais, M. Manning, Luther Robinson, M. Adam, O. Abdul-Rahman, T. Jewett, C. Coles, C. Chambers, K. Jones, C. Adnams, Prachi E Shah, E. Riley, M. E. Charness, K. Warren, P. May   +20 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Maternal-fetal Protection in Automobile Accidents and Reliability in the use of Existing Safety Belts [PDF]

, 2019
Sigrid Queiróz Cardoso, María Fernanda Cardoso, Jandecy Cabral Leite, Eneida Regina das Neves Nascimento, Manoel Henrique Reis Nascimento, Elisabeth Conceição de Oliveira Santos   +5 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Prenatally diagnosed fetal omphalocele at 11 week gestation — a case report [PDF]

, 2013
Zoran Protrka, Aleksandra Dimitrijević, Tatjana Kastratović, Janko Djurić, Petar Arsenijević, Tanja Novaković, Miloš Milosavljević   +6 more
openalex   +1 more source

Fetal and infant growth and impaired glucose tolerance at age 64.

British medical journal, 1991
C. Hales, D. Barker, P. Clark, L. Cox, C. Fall, C. Osmond, P. Winter   +6 more
semanticscholar   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source