Results 271 to 280 of about 129,591 (344)

Association Between Post‐Partum Anaemia and Depressive Symptoms at Two Months After Vaginal Delivery: A Secondary Analysis of the TRAAP Trial

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, Volume 132, Issue 11, Page 1644-1654, October 2025.
ABSTRACT Objective To assess the association between maternal haemoglobinaemia in the immediate post‐partum period and PPD symptoms 2 months after vaginal delivery. Design Ancillary cohort study of the TRAAP trial, a multicentre trial. Setting In France, 2015–2016. Population Women with a singleton pregnancy and vaginal delivery ≥ 35 weeks. We excluded
Lola Loussert   +26 more
wiley   +1 more source

JAK–STAT inhibitory effect of IN‐115314, a novel small molecule inhibitor, and pharmacokinetic/pharmacodynamic study in canine

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 20, Page 5071-5082, October 2025.
Abstract Background and Purpose The JAK–STAT signalling pathway has been extensively spotlighted as a therapeutic target for various diseases. This study assessed the inhibitory effects of a novel small molecule, IN‐115314, on JAK–STAT pathway. Experimental Approach The IC50 values of IN‐115314 for JAK1–pSTAT3 and JAK2–pSTAT5 were determined in canine ...
Jae‐Hun Ahn   +16 more
wiley   +1 more source

Contraception in Myeloproliferative Neoplasms: A Pharmacological Review

open access: yesEuropean Journal of Haematology, Volume 115, Issue 4, Page 344-348, October 2025.
ABSTRACT Myeloproliferative neoplasms (MPNs) are chronic hematologic disorders characterized by clonal proliferation of myeloid lineage cells, commonly driven by JAK2 mutations, and associated with significant thrombotic and hemorrhagic complications.
Awni Alshurafa   +4 more
wiley   +1 more source

Breaking Free From MCHC Interferences? French‐Speaking Cellular Haematology Group (GFHC) Review of Causes, Rising Trends and Practical Solutions

open access: yesInternational Journal of Laboratory Hematology, Volume 47, Issue 5, Page 798-807, October 2025.
ABSTRACT Mean corpuscular haemoglobin concentration (MCHC) is determined by the ratio of haemoglobin concentration to haematocrit. Managing increased MCHC presents significant challenges, mainly due to variations in analytical methods and pathophysiological conditions.
Sandrine Girard   +7 more
wiley   +1 more source

Yawning as Therapy? The Potential of the Conditioned Yawn Reflex as a Novel Treatment for Insomnia Disorder

open access: yesJournal of Sleep Research, Volume 34, Issue 5, October 2025.
ABSTRACT In 1986, Provine, the pioneer of yawning research wrote that ‘Yawning may have the dubious distinction of being the least understood, common human behaviour’ (p. 120); and so yawning remains some 40 years later, as something of a biological and social curiosity.
Colin A. Espie
wiley   +1 more source

Zinc Alleviates Gut Barrier Dysfunction by Promoting the Methylation of AKT

open access: yesAdvanced Science, Volume 12, Issue 33, September 4, 2025.
Zinc activates the ZNG1‐METAP1 complex to elevate intracellular SAM levels, which promotes PRMT5‐mediated symmetrical dimethylation of AKT at R391 and R15. This epigenetic modification facilitates AKT membrane translocation and mTORC2 activation, thereby enhancing epithelial proliferation and gut barrier integrity.
Chuanjiang Cai   +13 more
wiley   +1 more source

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