Results 241 to 250 of about 2,996,756 (310)

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

Feto-Maternal Microchimerism and the Brain: Mechanisms, Neurological Implications, and Translational Perspectives. [PDF]

Am J Reprod Immunol
Abey NO.
europepmc   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Evaluating cord blood S100B protein concentration as a potential biomarker associated with fetal hypoxia in late fetal growth restriction: A prospective cohort study protocol. [PDF]

PLoS One
Drozdowska-Szymczak A, Łukawska SA, Mazanowska N, Broniarek-Samson B, Zdulski J, Mierzejewska E, Issat T, Krajewski P.   +7 more
europepmc   +1 more source

Understanding physiological adaptations of pregnancy to the chronic hypoxia of high altitude to inform obstetrical and neonatal care. [PDF]

Physiol Rev
Arenas GA, Herrera EA, Krause BJ, Giussani DA, Julian CG, Moore LG, Lorca RA.   +6 more
europepmc   +1 more source

Research progress of cerebroplacental ratio in obstetric complications. [PDF]

Front Med (Lausanne)
Bi X, Qi R, Chen H.
europepmc   +1 more source

Inhibitory immune checkpoints in preeclampsia: current landscape, mechanisms, and clinical perspectives. [PDF]

Front Immunol
Liu M, Duan G, Lai X, Lin B, Li X, Yang J, Cao S, Chen H, Wang T, Chen B, He Z, Ma Q, Duan C, Zhu Y, Lu Y, Gao Y.   +15 more
europepmc   +1 more source

Evaluation of a Zika virus-like particle-based vaccine in a highly penetrant non-human primate model of congenital infection. [PDF]

PLoS Negl Trop Dis
Jaeger HK, Smith JL, Labriola CS, Pung LJ, Hagen OL, Denton M, D'Mello RJ, Parkins CJ, Weber WC, Medica S, Kreklywich CN, DeFilippis VR, Bondoc S, Busman-Sahay K, Castro JN, Zilverberg G, White R, Terry M, Barber-Axthelm AM, Axthelm MK, Smedley J, Aliota MT, Weiler AM, Friedrich TC, Estes J, Morgan TK, Lo JO, Roberts VHJ, Streblow DN, Hirsch AJ.   +29 more
europepmc   +1 more source

Fetal Hepatosplenomegaly: Stepwise Diagnostic Framework, Diagnostic Approach to Fetal Hepatosplenomegaly. [PDF]

J Clin Med
Mazek M, Ciebiera M, Massalska D.
europepmc   +1 more source