Results 61 to 70 of about 996,027 (306)

Toxoplasma Gondii Identification in Mother\u27s Blood and Fetal Tissue with Nested PCR [PDF]

, 2006
Toxoplasma gondii identification in mother’s blood and fetal tissue with nested PCRObjective: To examine the correlation between Toxoplasma gondii infection with spontaneous abortion on pregnant women based on nested PCR result from mother’s ...
Imada, M. (Mihoko), Masengi-Rumopa, J. A. (Juliana), Rahardjo, T. M. (Theresia), Suryawan, A. (Aloysius), Tuda, J. S. (Josef)   +4 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Measurement of Androgen and Estrogen Concentrations in Cord Blood: Accuracy, Biological Interpretation and Applications to Understanding Human Behavioural Development

Frontiers in Endocrinology, 2014
Accurately measuring hormone exposure during prenatal life presents a methodological challenge and there is currently no ‘gold standard’ approach. Ideally, circulating fetal hormone levels would be measured at repeated time points during pregnancy ...
Lauren P Hollier, Lauren P Hollier, Jeffrey A Keelan, Martha eHickey, Murray T Maybery, Andrew J.O. Whitehouse   +5 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Generation of a PDK-1 knockout human embryonic stem cell line by CRISPR/(WAe009-A-2K) Cas9 editing

Stem Cell Research
Pyruvate Dehydrogenase Kinase1 (PDK1) belongs to the family of kinases, regulates diverse metabolic processes. PDK1 is a susceptibility locus for heart failure via thinning of ventricle walls, and enlarged atria and ventricles.
Amina Saleem, Mingyu Wei, Muhammad Khawar Abbas, Siyao Zhang, Jiaqi Fan, Yang Xian, Hongfeng Jiang   +6 more
doaj   +1 more source

Effectiveness of fetal scalp stimulation test in assessing fetal wellbeing during labor, a retrospective cohort study

BMC Pregnancy and Childbirth, 2020
Background It is discussed whether fetal scalp stimulation (FSS) test is a reliable complimentary tool to cardiotocography (CTG) to assess fetal wellbeing during labor.
Farzaneh Shakouri, Linda Iorizzo, Hellen Mc Kinnon Edwards, Christina Anne Vinter, Karl Kristensen, Per-Erik Isberg, Nana Wiberg   +6 more
doaj   +1 more source

Placental MRI Predicts Fetal Oxygenation and Growth Rates in Sheep and Human Pregnancy

Advanced Science, 2022
Magnetic resonance imaging (MRI) assessment of fetal blood oxygen saturation (SO2) can transform the clinical management of high‐risk pregnancies affected by fetal growth restriction (FGR). Here, a novel MRI method assesses the feasibility of identifying
Dimitra Flouri, Jack R. T. Darby, Stacey L. Holman, Steven K. S. Cho, Catherine G. Dimasi, Sunthara R. Perumal, Sebastien Ourselin, Rosalind Aughwane, Nada Mufti, Christopher K. Macgowan, Mike Seed, Anna L. David, Andrew Melbourne, Janna L. Morrison   +13 more
doaj   +1 more source

A New Source of Stem Cells in Amniotic Fluid and Placenta in 1st Trimester of Pregnancy

, 2009
Mesenchymal stromal cells (MSC) are multipotent cells found in fetal, neonatal and adult tissues. Fetal MSC have advantageous characteristics over their adult counterparts, and the regenerative potential of fetal blood MSC has recently been shown in a
Moschidou, Dafni, Moschidou, Dafni
core   +1 more source

Myomectomy as a pregnancy-preserving option in the carefully selected patient [PDF]

, 2002
Objectives: To present the indications for myomectomy during pregnancy and to discuss complications possibly related and unrelated to the procedure. Method and Results: A 33-year-old patient at 18 weeks of gestation underwent removal of a 1,570-gram ...
Baretton, G., Hasbargen, U., Hepp, H., Kimmig, R., Roth, U., Strauss, A., Summerer-Moustaki, M.   +6 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source