Results 151 to 160 of about 938,719 (314)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Epigenetic Perspectives on Maternal Gut Microbiota's Impact on Embryonic and Fetal Development. [PDF]

Compr Physiol
Xu S, Huang Y, Hu C, Ding W, Pu Z, Li Q, Xu Z.   +6 more
europepmc   +1 more source

The Cognitive Link Between Geography and Development: Iodine Deficiency and Schooling Attainment in Tanzania [PDF]

An estimated 20 million children born each year are at risk of brain damage from in utero iodine deficiency, the only micronutrient deficiency known to have significant, non-reversible effects on cognitive development.
Máximo Torero, Omar Robles, Erica M. Field   +2 more
core  

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Associations of ambient temperature exposure with embryonic and early fetal development. [PDF]

Int J Epidemiol
Essers E, de Groot JM, Graafland N, Gonçalves R, Iñiguez C, Petricola S, Jaddoe V, El Marroun H, Tiemeier H, Steegers E, Rousian M, Mulders A, Guxens M.   +12 more
europepmc   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Lemborexant levels in maternal serum, cord blood, and breast milk during pregnancy and lactation: A case report

PCN Reports, 2023
Jumpei Saito, Mariko Ishii, Noriko Sandaiji, Koshi Yamaguchi, Tomo Suzuki, Naho Yakuwa, Akimasa Yamatani, Yoshiyuki Tachibana, Haruhiko Sago, Atsuko Murashima   +9 more
doaj   +1 more source

Evaluating chemotherapy-driven placental alterations and their impact on fetal development. [PDF]

Front Toxicol
De Clercq K, Velazquez C, Persoons E, Wolters V, Van de Ven M, Amant F.   +5 more
europepmc   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Glucocorticoid Receptor Signaling: Multilevel Organization, Roles in Fetal Development, and Postnatal Outcomes. [PDF]

Int J Mol Sci
Potapova S, Isakov Y, Tyulkova E, Vetrovoy O.   +3 more
europepmc   +1 more source