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Fetal nutrition and adult disease [PDF]
The American Journal of Clinical Nutrition, 2000 Recent research suggests that several of the major diseases of later life, including coronary heart disease, hypertension, and type 2 diabetes, originate in impaired intrauterine growth and development. These diseases may be consequences of "programming," whereby a stimulus or insult at a critical, sensitive period of early life has permanent effects ...
Keith M. Godfrey, David J.P. Barker
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Fetal origins of cardiovascular disease [PDF]
Annals of Medicine, 1999 Low birthweight, thinness and short body length at birth are now known to be associated with increased rates of cardiovascular disease and non-insulin dependent diabetes in adult life. The fetal origins hypothesis proposes that these diseases originate through adaptations which the fetus makes when it is undernourished.
David J.P. Barker
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The fetal origins of adult disease [PDF]
BMJ, 2001 David Barker pioneered the idea that the 20th century epidemic of coronary heart disease in Western countries might have originated in fetal life.1 Paradoxically, the epidemic coincided with improved standards of living and nutrition, yet in Britain its greatest impact was in the most deprived areas.
R. Robinson
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Antenatal management of fetal neurosurgical diseases [PDF]
Child's Nervous System, 2017 The advance in the imaging tools during the pregnancy (ultrasound and magnetic resonance) allowed the early diagnose of many fetal diseases, including the neurological conditions. This progress brought the neurosurgeons the possibility to propose treatments even before birth.
Cavalheiro, Sergio UNIFESP +6 more
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Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease
Frontiers in Immunology, 2020 Events in fetal life impact long-term health outcomes. The placenta is the first organ to form and is the site of juxtaposition between the maternal and fetal circulations.
Jeffery A. Goldstein +4 more
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Fetal Origins of Adult Disease Fetal Origins Of Adult Disease? [PDF]
Clinical and Experimental Pharmacology and Physiology, 2001 SUMMARY1. Associations between lower birthweight and higher blood pressure, increased risk of type 2 diabetes and coronary heart disease (CHD) have been observed in a number of different populations worldwide.2. The reason for this is still debated. Some believe that the observed associations can be explained on the basis of differences in postnatal ...
Ruth Morley, Terence Dwyer
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The fetal origin of adult diseases
Journal of Obstetrics and Gynaecology, 2003 In the last decade, the development of Barker's hypothesis of fetal programming opened the field for extensive research into the fetal origin of adult diseases. The association between low birth weight, which reflects intrauterine nutritional status, and the development of adult diseases has been confirmed in many studies for type 2 diabetes ...
Mark Walker, B Sallout
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Fetal and obstetrics manifestations of mitochondrial diseases
Journal of Translational MedicineDuring embryonic and neonatal development, mitochondria have essential effects on metabolic and energetic regulation, shaping cell fate decisions and leading to significant short- and long-term effects on embryonic and offspring health.
Alessia Adelizzi +9 more
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Beyond liver cancer, more application scenarios for alpha-fetoprotein in clinical practice
Frontiers in Oncology, 2023 Alpha-fetoprotein (AFP) is a commonly used clinical biomarker. Before 1970, the two-way agar diffusion method was mainly used, and the specificity of AFP in the diagnosis of primary liver cancer was satisfactory. However, its positivity rate was not very
Chenyu Ma +4 more
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SARS-CoV-2 Placentitis Associated With B.1.617.2 (Delta) Variant and Fetal Distress or Demise
Journal of Infectious Diseases, 2022 There is limited information on the specific impact of maternal infection with the SARS-CoV-2 B.1.617.2 (delta) variant on pregnancy outcomes. We present 2 cases of intrauterine fetal demise and 1 case of severe fetal distress in the setting of maternal ...
L. Shook +10 more
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