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Fetal nutrition and adult disease [PDF]

open access: yesThe American Journal of Clinical Nutrition, 2000
Recent research suggests that several of the major diseases of later life, including coronary heart disease, hypertension, and type 2 diabetes, originate in impaired intrauterine growth and development. These diseases may be consequences of "programming," whereby a stimulus or insult at a critical, sensitive period of early life has permanent effects ...
K M, Godfrey, D J, Barker
openaire   +3 more sources

SARS-CoV-2 Placentitis Associated With B.1.617.2 (Delta) Variant and Fetal Distress or Demise

open access: yesJournal of Infectious Diseases, 2022
There is limited information on the specific impact of maternal infection with the SARS-CoV-2 B.1.617.2 (delta) variant on pregnancy outcomes. We present 2 cases of intrauterine fetal demise and 1 case of severe fetal distress in the setting of maternal ...
L. Shook   +10 more
semanticscholar   +1 more source

Role of Regulatory T Cells in Regulating Fetal-Maternal Immune Tolerance in Healthy Pregnancies and Reproductive Diseases

open access: yesFrontiers in Immunology, 2020
Regulatory T cells (Tregs) are a specialized subset of T lymphocytes that function as suppressive immune cells and inhibit various elements of immune response in vitro and in vivo.
N. Huang, H. Chi, J. Qiao
semanticscholar   +1 more source

The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases

open access: yesBiological Trace Element Research, 2020
Magnesium is an essential trace metal and a necessary factor for multiple biochemical functions in humans. Its role in biology is fundamental in over 600 enzymatic reactions implicated in protein synthesis, mitochondrial functions, neuromuscular activity,
D. Fanni   +11 more
semanticscholar   +1 more source

Effects of Prenatal Hypoxia on Nervous System Development and Related Diseases

open access: yesFrontiers in Neuroscience, 2021
The fetal origins of adult disease (FOAD) hypothesis, which was proposed by David Barker in the United Kingdom in the late 1980s, posited that adult chronic diseases originated from various adverse stimuli in early fetal development.
Bin Wang   +3 more
semanticscholar   +1 more source

Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease

open access: yesFrontiers in Immunology, 2020
Events in fetal life impact long-term health outcomes. The placenta is the first organ to form and is the site of juxtaposition between the maternal and fetal circulations.
J. Goldstein   +4 more
semanticscholar   +1 more source

Antenatal management of fetal neurosurgical diseases

open access: yesChild's Nervous System, 2017
The advance in the imaging tools during the pregnancy (ultrasound and magnetic resonance) allowed the early diagnose of many fetal diseases, including the neurological conditions.
S. Cavalheiro   +6 more
semanticscholar   +1 more source

Fetal programming and early identification of newborns at high risk of free radical-mediated diseases.

open access: yesWorld Journal of Clinical Pediatrics, 2016
Nowadays metabolic syndrome represents a real outbreak affecting society. Paradoxically, pediatricians must feel involved in fighting this condition because of the latest evidences of developmental origins of adult diseases. Fetal programming occurs when
S. Perrone   +3 more
semanticscholar   +1 more source

Severe Acute Respiratory Syndrome Coronavirus 2 Placental Infection and Inflammation Leading to Fetal Distress and Neonatal Multi-Organ Failure in an Asymptomatic Woman

open access: yesJournal of the Pediatric Infectious Diseases Society, 2020
Placental severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a specific histiocytic intervillositis. Placental fibrin depositions can decrease the maternal-fetal interface causing fetal distress. Coronavirus disease
S. Schoenmakers   +12 more
semanticscholar   +1 more source

Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development.

open access: yesImmunity, 2018
Successful pregnancy requires carefully-coordinated communications between the mother and fetus. Immune cells and cytokine signaling pathways participate as mediators of these communications to promote healthy pregnancy.
L. Yockey, A. Iwasaki
semanticscholar   +1 more source

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