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Fetal origins of cardiovascular disease [PDF]
Annals of Medicine, 1999 Low birthweight, thinness and short body length at birth are now known to be associated with increased rates of cardiovascular disease and non-insulin dependent diabetes in adult life. The fetal origins hypothesis proposes that these diseases originate through adaptations which the fetus makes when it is undernourished.
David J.P. Barker
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Fetal microchimeric cells in blood of women with an autoimmune thyroid disease. [PDF]
PLoS ONE, 2011 ContextHashimoto's thyroiditis (HT) and Graves' disease (GD), two autoimmune thyroid diseases (AITD), occur more frequently in women than in men and show an increased incidence in the years following parturition.
Trees Lepez +7 more
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Fetal nutrition and adult disease [PDF]
The American Journal of Clinical Nutrition, 2000 Recent research suggests that several of the major diseases of later life, including coronary heart disease, hypertension, and type 2 diabetes, originate in impaired intrauterine growth and development. These diseases may be consequences of "programming," whereby a stimulus or insult at a critical, sensitive period of early life has permanent effects ...
David J.P. Barker, Keith M. Godfrey
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The Fetal Origins of the Metabolic Syndrome: Can We Intervene? [PDF]
Journal of Pregnancy, 2012 Epidemiological studies have suggested that metabolic programming begins during fetal life and adverse events in utero are a critical factor in the etiology of chronic diseases and overall health.
Noelle Ma, Daniel B. Hardy
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The fetal origins of adult disease [PDF]
BMJ, 2001 David Barker pioneered the idea that the 20th century epidemic of coronary heart disease in Western countries might have originated in fetal life.1 Paradoxically, the epidemic coincided with improved standards of living and nutrition, yet in Britain its greatest impact was in the most deprived areas.
R. Robinson
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Fetal Origins of Adult Disease Fetal Origins Of Adult Disease? [PDF]
Clinical and Experimental Pharmacology and Physiology, 2001 SUMMARY1. Associations between lower birthweight and higher blood pressure, increased risk of type 2 diabetes and coronary heart disease (CHD) have been observed in a number of different populations worldwide.2. The reason for this is still debated. Some believe that the observed associations can be explained on the basis of differences in postnatal ...
Ruth Morley, Terence Dwyer
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Scientific Reports, 2021 Total anomalous pulmonary venous connection (TAPVC) is a rare congenital cardiac malformation, and prenatal detection of TAPVC malformation remains a challenging. TAPVC can be easily missed or misdiagnosed in prenatal examinations.
Jiaqi Zhang +7 more
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Beyond liver cancer, more application scenarios for alpha-fetoprotein in clinical practice
Frontiers in Oncology, 2023 Alpha-fetoprotein (AFP) is a commonly used clinical biomarker. Before 1970, the two-way agar diffusion method was mainly used, and the specificity of AFP in the diagnosis of primary liver cancer was satisfactory. However, its positivity rate was not very
Chenyu Ma +4 more
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Protocols for the Evaluation of Neurodevelopmental Alterations in Rabbit Models In Vitro and In Vivo
Frontiers in Toxicology, 2022 The rabbit model is gaining importance in the field of neurodevelopmental evaluation due to its higher similarity to humans in terms of brain development and maturation than rodents.
Laura Pla +11 more
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Open Medicine, 2023 Today, in the modern world, people are often exposed to electromagnetic waves, which can have undesirable effects on cell components that lead to differentiation and abnormalities in cell proliferation, deoxyribonucleic acid (DNA) damage, chromosomal ...
Kashani Zahra Atarodi +7 more
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