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Fetal origins of cardiovascular disease [PDF]

Annals of Medicine, 1999
Low birthweight, thinness and short body length at birth are now known to be associated with increased rates of cardiovascular disease and non-insulin dependent diabetes in adult life. The fetal origins hypothesis proposes that these diseases originate through adaptations which the fetus makes when it is undernourished.
David J.P. Barker
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The fetal origins of adult disease [PDF]

BMJ, 2001
David Barker pioneered the idea that the 20th century epidemic of coronary heart disease in Western countries might have originated in fetal life.1 Paradoxically, the epidemic coincided with improved standards of living and nutrition, yet in Britain its greatest impact was in the most deprived areas.
R. Robinson
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Oxidative stress in pediatric diseases associated with the origin of life and growth and development [PDF]

Frontiers in Cell and Developmental Biology
The presence of oxidative stress and an imbalance in antioxidant mechanisms have been demonstrated in numerous diseases. Furthermore, mounting evidence suggests that the occurrence, progression, and prognosis of certain pediatric diseases linked to the ...
Bo Zheng, Jianhua Fu
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Fetal nutrition and adult disease [PDF]

The American Journal of Clinical Nutrition, 2000
Recent research suggests that several of the major diseases of later life, including coronary heart disease, hypertension, and type 2 diabetes, originate in impaired intrauterine growth and development. These diseases may be consequences of "programming," whereby a stimulus or insult at a critical, sensitive period of early life has permanent effects ...
Keith M. Godfrey, David J.P. Barker
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Fetal Origins of Adult Disease Fetal Origins Of Adult Disease? [PDF]

Clinical and Experimental Pharmacology and Physiology, 2001
SUMMARY1. Associations between lower birthweight and higher blood pressure, increased risk of type 2 diabetes and coronary heart disease (CHD) have been observed in a number of different populations worldwide.2. The reason for this is still debated. Some believe that the observed associations can be explained on the basis of differences in postnatal ...
Ruth Morley, Terence Dwyer
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Fetal and obstetrics manifestations of mitochondrial diseases

Journal of Translational Medicine
During embryonic and neonatal development, mitochondria have essential effects on metabolic and energetic regulation, shaping cell fate decisions and leading to significant short- and long-term effects on embryonic and offspring health.
Alessia Adelizzi, Anastasia Giri, Alessia Di Donfrancesco, Simona Boito, Alessandro Prigione, Emanuela Bottani, Valentina Bollati, Valeria Tiranti, Nicola Persico, Dario Brunetti   +9 more
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Beyond liver cancer, more application scenarios for alpha-fetoprotein in clinical practice

Frontiers in Oncology, 2023
Alpha-fetoprotein (AFP) is a commonly used clinical biomarker. Before 1970, the two-way agar diffusion method was mainly used, and the specificity of AFP in the diagnosis of primary liver cancer was satisfactory. However, its positivity rate was not very
Chenyu Ma, Yuexinzi Jin, Yuhan Wang, Huaguo Xu, Jiexin Zhang   +4 more
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Utility of a modified vascular corrosion casting technique in the diagnosis of fetal total anomalous pulmonary venous connection

Scientific Reports, 2021
Total anomalous pulmonary venous connection (TAPVC) is a rare congenital cardiac malformation, and prenatal detection of TAPVC malformation remains a challenging. TAPVC can be easily missed or misdiagnosed in prenatal examinations.
Jiaqi Zhang, Wei Feng, Qiaoyue He, Hongzhi Guo, He Zeng, Ziyi Si, Ya Liu, Yu Wang   +7 more
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Protocols for the Evaluation of Neurodevelopmental Alterations in Rabbit Models In Vitro and In Vivo

Frontiers in Toxicology, 2022
The rabbit model is gaining importance in the field of neurodevelopmental evaluation due to its higher similarity to humans in terms of brain development and maturation than rodents.
Laura Pla, Britta Anna Kühne, Britta Anna Kühne, Laia Guardia-Escote, Laia Guardia-Escote, Paula Vázquez-Aristizabal, Paula Vázquez-Aristizabal, Carla Loreiro, Burkhard Flick, Eduard Gratacós, Marta Barenys, Miriam Illa   +11 more
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Electromagnetic fields exposure on fetal and childhood abnormalities: Systematic review and meta-analysis

Open Medicine, 2023
Today, in the modern world, people are often exposed to electromagnetic waves, which can have undesirable effects on cell components that lead to differentiation and abnormalities in cell proliferation, deoxyribonucleic acid (DNA) damage, chromosomal ...
Kashani Zahra Atarodi, Pakzad Reza, Fakari Farzaneh Rashidi, Haghparast Mohammad Sadegh, Abdi Fatemeh, Kiani Zohreh, Talebi Afsaneh, Haghgoo Somaieh Moradi   +7 more
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