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Fetal nutrition and adult disease [PDF]
The American Journal of Clinical Nutrition, 2000 Recent research suggests that several of the major diseases of later life, including coronary heart disease, hypertension, and type 2 diabetes, originate in impaired intrauterine growth and development. These diseases may be consequences of "programming," whereby a stimulus or insult at a critical, sensitive period of early life has permanent effects ...
David J.P. Barker, Keith M. Godfrey
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Fetal origins of cardiovascular disease [PDF]
Annals of Medicine, 1999 Low birthweight, thinness and short body length at birth are now known to be associated with increased rates of cardiovascular disease and non-insulin dependent diabetes in adult life. The fetal origins hypothesis proposes that these diseases originate through adaptations which the fetus makes when it is undernourished.
David J.P. Barker
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Antenatal management of fetal neurosurgical diseases [PDF]
Child's Nervous System, 2017 The advance in the imaging tools during the pregnancy (ultrasound and magnetic resonance) allowed the early diagnose of many fetal diseases, including the neurological conditions. This progress brought the neurosurgeons the possibility to propose treatments even before birth.
Cavalheiro, Sergio UNIFESP +6 more
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The fetal origins of adult disease [PDF]
BMJ, 2001 David Barker pioneered the idea that the 20th century epidemic of coronary heart disease in Western countries might have originated in fetal life.1 Paradoxically, the epidemic coincided with improved standards of living and nutrition, yet in Britain its greatest impact was in the most deprived areas.
R. Robinson
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The fetal origin of adult diseases
Journal of Obstetrics and Gynaecology, 2003 In the last decade, the development of Barker's hypothesis of fetal programming opened the field for extensive research into the fetal origin of adult diseases. The association between low birth weight, which reflects intrauterine nutritional status, and the development of adult diseases has been confirmed in many studies for type 2 diabetes ...
Mark Walker, B Sallout
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Fetal programming and future disease [PDF]
Revista do Hospital das Clínicas, 2004 Recent epidemiological studies have demonstrated a close relationship between low birth weight and a high predisposition to arterial hypertension, hyperlipidemia and non-insulin-dependent diabetes in adulthood. These findings may coexist as Syndrome X, more recently named as Metabolic Syndrome, and understood as precursory of coronary heart disease and
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Fetal Origins of Adult Disease [PDF]
Current Problems in Pediatric and Adolescent Health Care, 2011 Dr. David Barker first popularized the concept of fetal origins of adult disease (FOAD). Since its inception, FOAD has received considerable attention. The FOAD hypothesis holds that events during early development have a profound impact on one's risk for development of future adult disease. Low birth weight, a surrogate marker of poor fetal growth and
Kara L. Calkins, Sherin U. Devaskar
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Fetal roots of cardiac disease [PDF]
Heart, 2005 In western countries, cardiovascular disease is the leading killer of men and women. In the past decade, it has become increasingly clear that women are just as vulnerable to heart disease as men. In 2004, the number of women with some form of the disease will exceed the number of such men in the USA (www.americanheart.org).
Kent L. Thornburg, Samantha Louey
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The maternal and fetal origins of cardiovascular disease. [PDF]
Journal of Epidemiology & Community Health, 1992 This chapter presents evidence that restraint of growth and development during critical periods of fetal life and infancy have an important effect on the development of cardiovascular disease.
Christopher Martyn, D. J. P. Barker
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Fetal origins of coronary heart disease. [PDF]
Heart, 1993 The fetal origins hypothesis states that fetal undernutrition in middle to late gestation, which leads to disproportionate fetal growth, programmes later coronary heart disease. Animal studies have shown that undernutrition before birth programmes persisting changes in a range of metabolic, physiological, and structural parameters.
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