Results 91 to 100 of about 886,120 (360)

Prenatal tobacco smoke exposure increases hospitalizations for bronchiolitis in infants [PDF]

, 2015
BACKGROUND: Tobacco smoke exposure (TSE) is a worldwide health problem and it is considered a risk factor for pregnant women's and children's health, particularly for respiratory morbidity during the first year of life.
Adorni F, Agosti M, Aurilia C, Barberi I, Barboni G, Bertino E, Boldrini A, Bonomi A, Bottau P, Braibanti S, Carlucci A, Corona MF, Corsello G, Corso G, Coscia A, Dall’Agnola A, De Curtis M, De Luca MG, Del Vecchio A, Di Fabio S, Di Santo S, Ellero S, Fabiano A, Fabris C, Faccia P, Fanos V, Gabriele B, Gargano G, Gaudino M, Girardi E, La Forgia N, Ladetto L, Lanari M, Loprieno S, Macagno F, Magaldi R, Memo L, Molinari L, Musicco M, Natale F, Negri C, Ngalikpima CJ, Nicolini G, Nosari N, Orfeo L, Paolillo P, Parmigiani S, Piano F, Prinelli F, Puddu M, Rinaldi M, Romagnoli C, Sarnelli P, Silvestri M, Spinelli M, Umbaldo A, Vandini S, Vuerich M, Zorzi G, ” Faldella G   +59 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Nondestructive Identification of Rare Trophoblastic Cells by Endoplasmic Reticulum Staining for Noninvasive Prenatal Testing of Monogenic Diseases

Advanced Science, 2020
Noninvasive prenatal detection of monogenic diseases based on cell‐free DNA is hampered by challenges in obtaining a sufficient fraction and adequate quality of fetal DNA.
Yifang Huang, Bo Situ, Liping Huang, Yingsi Cao, Hong Sui, Xinyi Ye, Xiujuan Jiang, Aifen Liang, Maliang Tao, Shihua Luo, Ye Zhang, Mei Zhong, Lei Zheng   +12 more
doaj   +1 more source

Mother-child histocompatibility and risk of rheumatoid arthritis and systemic lupus erythematosus among mothers. [PDF]

, 2020
The study objective was to test the hypothesis that having histocompatible children increases the risk of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), possibly by contributing to the persistence of fetal cells acquired during ...
Barcellos, Lisa F, Blasczyk, Rainer, Busch, Michael P, Criswell, Lindsey A, Cruz, Giovanna I, Ho, Kimberly A, Ladas, Nektarios, Niederhuber, John E, Noble, Janelle A, Patsopoulos, Nikolaos A, Quach, Diana, Quach, Hong, Shao, Xiaorong, Solomon, Benjamin D, Sterba, Kirsten, Triulzi, Darrell J, Wong, Wendy SW   +16 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Chromosomal abnormalities associated with fetal pleural effusion (I): General overview

Taiwanese Journal of Obstetrics & Gynecology
Fetal pleural effusion has been reported to be associated with chromosomal abnormalities, genetic syndromes, obstructive uropathy, lymphatic vessel abnormalities such as Noonan syndrome, RASopathy and congenital lymphatic anomalies, thoracic cavity ...
Chih-Ping Chen
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Commentary: Planning ahead: Fetal magnetic resonance imaging may predict brain injury before surgery for congenital heart disease [PDF]

, 2020
Mohan J. John, Travis J. Wilder
openalex   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The Fetal Origins of the Metabolic Syndrome: Can We Intervene?

Journal of Pregnancy, 2012
Epidemiological studies have suggested that metabolic programming begins during fetal life and adverse events in utero are a critical factor in the etiology of chronic diseases and overall health.
Noelle Ma, Daniel B. Hardy
doaj   +1 more source