Results 121 to 130 of about 2,686,479 (312)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

FERPIR promotes cardiomyocyte survival and attenuates cardiac remodeling after myocardial infarction

Cell Death and Disease
PIWI-interacting RNAs (piRNAs) are widely expressed in cardiac tissues and play important roles in cardiac pathophysiology. However, their functions and molecular mechanisms in cardiac remodeling following myocardial infarction (MI) and cardiomyocyte ...
Ruiquan Wang, Xinzhe Chen, Jiahao Ren, Shen Hu, Fang Liu, Luyu Zhou, Xinmin Li, Shijun Xu, Junqiang Xue, Sumin Yang, Meihua Zhang, Yunhong Wang, Kun Wang, Cuiyun Liu   +13 more
doaj   +1 more source

Fetal alcohol spectrum disorders: current issues in awareness, prevention and intervention [PDF]

, 2014
This paper reviews the research and current policy surrounding prenatal alcohol exposure and fetal alcohol spectrum disorders (FASD). Alcohol use during pregnancy is linked to a spectrum of adverse fetal outcomes.
Sara McLean, Stewart McDougall
core  

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Placental malaria induces a unique methylation profile associated with fetal growth restriction

Epigenetics
Fetal growth restriction (FGR) is associated with perinatal death and adverse birth outcomes, as well as long-term complications, including increased childhood morbidity, abnormal neurodevelopment, and cardio-metabolic diseases in adulthood.
Nida Ozarslan, Corina Mong, John Ategeka, Lin Li, Sirirak Buarpung, Joshua F. Robinson, Jimmy Kizza, Abel Kakuru, Moses R. Kamya, Grant Dorsey, Philip J. Rosenthal, Stephanie L. Gaw   +11 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Complete mole with co-existing fetus: a rare case report of full-term delivery with favorable maternal and fetal outcomes

Taiwanese Journal of Obstetrics & Gynecology
Objective: To explore the obstetric and oncological outcomes of CHMCF and to give a beneficial reference for the individualized management of the disease and the timing of pregnancy termination.
Hu Liuqin, Wang Na, Zhang Huimin, Li Shaoying, Xie Yinong, Yuan Zhiguang, Chen min, Li Yingtao, Li Zhihua, Chen Dunjin   +9 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Biodistribution of Polymeric Nanoparticles following in utero Delivery to a Nonhuman Primate

Biomedicine Hub
Introduction: Monogenic diseases can be diagnosed before birth. Systemic fetal administration of nanoparticles (NPs) grants therapeutic access to developing stem cell populations impacted by these classes of disease.
David A. Eaton, Anna Y. Lynn, Juliana M. Surprenant, Emily I. Deschenes, Mary Elizabeth Guerra, Rachel Rivero, Nicholas K. Yung, Merissa O'Connor, Peter M. Glazer, Mert Ozan Bahtiyar, W. Mark Saltzman, David H. Stitelman   +11 more
doaj   +1 more source